tumor suppressor gene

noun

Definition of tumor suppressor gene

  1. :  any of a class of genes (such as p53) that act in normal cells to inhibit unrestrained cell division and that when inactivated (as by mutation) place the cell at increased risk for malignant proliferation

First Known Use of tumor suppressor gene

1985


Medical Dictionary

tumor suppressor gene

noun
variants: or

tumor–suppressor gene

Medical Definition of tumor suppressor gene

  1. :  any of a class of genes (as p53 and APC) that act in normal cells to inhibit unrestrained cell division and that when inactivated (as by mutation) place the cell at increased risk for malignant proliferation In some cases [of cancer], growth-inhibiting genes called tumor suppressor genes are damaged, allowing cells to proliferate unchecked.—Faye Flam, The Philadelphia Inquirer, 29 Sept. 2010 In most human-cancer cells, there are multiple mutations—some that activate oncogenes and some that silence tumor-suppressor genes.—Robert A. Weinberg and Anthony L. Komaroff, Newsweek, 23 June 2008—called also anti-oncogene


Seen and Heard

What made you want to look up tumor suppressor gene? Please tell us where you read or heard it (including the quote, if possible).

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!

WORD OF THE DAY

conspicuously offensive

Get Word of the Day daily email!

Test Your Vocabulary

Time Traveler Quiz: Which Word Came First?

  • time-traveler-quiz-which-word-came-first
  • Which came first?
Name That Thing

Test your visual vocabulary with our 10-question challenge!

TAKE THE QUIZ
SCRABBLE® Sprint

Test Your Knowledge - and learn some interesting things along the way.

TAKE THE QUIZ

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!