1
2
: the base on which an organism lives
the soil is the substrate of most seed plants
3
: a substance acted upon (as by an enzyme)

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With its Latin prefix sub-, "below", substrate obviously refers to a layer under something else. Rock may serve as the substrate for the coral in a coral reef. Tiny wafers of silicon (or another semiconductor) serve as the substrate for computer chips. Substrate may also mean subsoil—that is, the layer under the topsoil, lacking in organic matter or humus. Substrate is part of the vocabulary of various other sciences, including chemistry and biology. But although it's mostly a scientific term, writers may also use it to mean simply "foundation"—for instance, when observing that reading is the substrate on which most other learning is based.

Examples of substrate in a Sentence

Recent Examples on the Web
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Toto makes ceramic electrostatic chucks used in semiconductor manufacturing equipment, while Nittobo supplies advanced glass fiber used in semiconductor package substrates. Lim Hui Jie, CNBC, 22 July 2026 As a carbohydrate, rice is an excellent food (substrate) for bacterial growth. Amy Brownstein, Verywell Health, 17 July 2026 Quandt claims that both foldables will have a less visible crease thanks to a new titanium substrate material teased by the company. Kimberly Gedeon, PC Magazine, 17 July 2026 The center dome is manufactured using a chemical vapor deposition process, where diamond is grown as a crystalline layer before the substrate is removed, leaving a self-supporting diamond dome. Mark Sparrow, Forbes.com, 10 July 2026 See All Example Sentences for substrate

Word History

Etymology

Medieval Latin substratum

First Known Use

1730, in the meaning defined at sense 1

Time Traveler
The first known use of substrate was in 1730

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Cite this Entry

“Substrate.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/substrate. Accessed 24 Jul. 2026.

Kids Definition

1
: an underlying layer: as
b
: the base on which an organism lives or over which it moves
the soil is the substrate of most plants
2
: a substance acted upon (as by an enzyme)

Medical Definition

1
2
: the base on which an organism lives
3
: a substance acted upon (as by an enzyme)

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