1
2
: the base on which an organism lives
the soil is the substrate of most seed plants
3
: a substance acted upon (as by an enzyme)

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With its Latin prefix sub-, "below", substrate obviously refers to a layer under something else. Rock may serve as the substrate for the coral in a coral reef. Tiny wafers of silicon (or another semiconductor) serve as the substrate for computer chips. Substrate may also mean subsoil—that is, the layer under the topsoil, lacking in organic matter or humus. Substrate is part of the vocabulary of various other sciences, including chemistry and biology. But although it's mostly a scientific term, writers may also use it to mean simply "foundation"—for instance, when observing that reading is the substrate on which most other learning is based.

Examples of substrate in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Future electronic devices Elliot Kisiel, PhD, a Maria Goeppert Mayer fellow at ANL, as well as lead author of the study, stated that the team initially suspected the unexpected response in the sapphire substrate was an experimental artifact. — Georgina Jedikovska, Interesting Engineering, 2 Oct. 2026 The silicon SoC and the unified memory are both packaged directly onto the processor substrate, and even the internal SSD modules are locked from user replacement or end-user servicing without specialized diagnostic tools. — Brian Westover, PC Magazine, 1 Oct. 2026 The More Conventional Approach​ Conversely, much of the industry, led by Nvidia, has embraced the chip-on-wafer-on-substrate (CoWoS) solution to the memory wall. — Nandan Nayampally, Forbes.com, 28 Sep. 2026 Unlike the rigid glass surface of a standard smartphone, foldables use an OLED display mounted on a flexible plastic substrate and covered with ultra-thin glass (UTG) that's thinner than a human hair and capable of bending. — Stephen J. Beard, USA Today, 9 Sep. 2026 See All Example Sentences for substrate

Word History

Etymology

Medieval Latin substratum

First Known Use

1730, in the meaning defined at sense 1

Time Traveler
The first known use of substrate was in 1730

Browse Nearby Words

Cite this Entry

“Substrate.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/substrate. Accessed 8 Oct. 2026.

Kids Definition

1
: an underlying layer: as
b
: the base on which an organism lives or over which it moves
the soil is the substrate of most plants
2
: a substance acted upon (as by an enzyme)

Medical Definition

1
2
: the base on which an organism lives
3
: a substance acted upon (as by an enzyme)
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