pro·​te·​ome | \ ˈprō-tē-ˌōm How to pronounce proteome (audio) \

Definition of proteome

: the complement of proteins expressed in a cell, tissue, or organism by a genome

Examples of proteome in a Sentence

Recent Examples on the Web Their algorithm gobbled up the entire human proteome and spat out a preliminary list of about 43,000 peptides. Max G. Levy, Wired, 30 Nov. 2021 Nautilus is developing a protein analysis platform with the goal to identify more than 95% of the proteome. John Cumbers, Forbes, 16 June 2021 Across the board, AlphaFold2 predicted 58% of amino acids in the human proteome — all the proteins expressed by the human body — with confidence, and 35.7% with a very high degree of confidence. Katie Palmer, STAT, 22 July 2021 Until recently, studying the proteome was extremely challenging. John Cumbers, Forbes, 16 June 2021 Their effort centers on building a proteome — the complete collection of proteins that LECA was probably capable of making. Quanta Magazine, 9 Apr. 2019 Moses’ lab, which receives support from the NIH, foundations, and philanthropic organizations, looks at how cancer affects an individual’s protein profile, or proteome, and compares the presence of these proteins in urine samples., 27 Sep. 2019 In 2012, Keith Dunker of Indiana University and his colleagues looked for these telltale stretches of amino acids in databases of eukaryotic and prokaryotic proteomes. Quanta Magazine, 24 Jan. 2017 Instead of identifying them one protein at a time, as has classically been done, Cravatt develops rules that apply to wide swathes of the universe of proteins, or the proteome. Bradley J. Fikes,, 16 Oct. 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'proteome.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of proteome

1995, in the meaning defined above

History and Etymology for proteome

prote(in) + -ome (in genome)

Note: The term was first used in print in Valerie C. Wasinger, et al., "Progress with gene-product mapping of the Mollicutes: Mycoplasma genitalium," Electrophoresis, vol. 16, no. 7 (July, 1995), pp. 1090-94. According to Wikipedia (as of 6/30/21), proteome was coined by the Australian geneticist Marc R. Wilkins; see Marc R. Wilkins, et al., "Progress with Proteome Projects: Why All Proteins Expressed by a Genome Should be Identified and How To Do It," Biotechnology and Genetic Engineering Reviews, vol. 13 (1996), pp. 19-50; and Marc R. Wilkins, et al., "From Proteins to Proteomes: Large Scale Protein Identification by Two-Dimensional Electrophoresis and Amino Acid Analysis," Nature Biotechnology, vol. 14, issue 1 (January, 1996), pp. 61-65.

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The first known use of proteome was in 1995

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Last Updated

13 Dec 2021

Cite this Entry

“Proteome.” Dictionary, Merriam-Webster, Accessed 28 Jan. 2022.

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More Definitions for proteome


pro·​te·​ome | \ ˈprōt-ē-ˌōm How to pronounce proteome (audio) \

Medical Definition of proteome

: the complement of proteins expressed in a cell, tissue, or organism by a genome


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