phenylephrine

noun

phen·​yl·​eph·​rine ˌfe-nᵊl-ˈe-ˌfrēn 

-frən

: a sympathomimetic agent C₉H₁₃NO₂ that is used in the form of its hydrochloride as a vasoconstrictor, a mydriatic, a nasal decongestant, and by injection to raise the blood pressure

Examples of phenylephrine in a Sentence

Recent Examples on the Web

Nasal decongestants: Nasal decongestants such as Sudafed (phenylephrine) can help reduce congestion and a stuffy nose. —Carrie Madormo, Health, 28 Nov. 2025

In fact, a 2023 advisory panel to the U.S. Food and Drug Administration (FDA) unanimously concluded that current data does not support the effectiveness of oral phenylephrine as a decongestant. —Daryl Austin, USA Today, 19 Nov. 2025

Hemorrhoid Creams Over-the-counter creams for hemorrhoid treatment contain ingredients such as phenylephrine, which narrows blood vessels and reduces swelling. —Heather Jones, Verywell Health, 14 July 2025

Nasal sprays containing phenylephrine are also a good way to manage congestion—but Dr. Johnson advises against using them for more than a few days to avoid becoming dependent on them. —Ashley Abramson, SELF, 12 Feb. 2025

Word History

Etymology

phenyl + epinephrine

First Known Use

circa 1947, in the meaning defined above

Rhymes for phenylephrine

• acetylene
• adenosine
• amphetamine
• anthropocene
• antipyrine
• apomorphine
• apoprotein
• aquamarine
• arsphenamine
• azobenzene
• buprenorphine
• chlorobenzene

Medical Definition

phenylephrine

noun

phen·​yl·​eph·​rine ˌfen-ᵊl-ˈef-ˌrēn, -rən 

: a sympathomimetic agent with vasoconstrictive properties that is used in the form of its hydrochloride C₉H₁₃NO₂·HCl especially as a nasal decongestant and mydriatic and to raise blood pressure

Note: Trademarks for preparations containing phenylephrine include Actifed and Neo-Synephrine.