buprenorphine

noun

bu·​pre·​nor·​phine ˌbyü-prə-ˈnȯr-ˌfēn 

-fən

: a semisynthetic narcotic analgesic that is administered in the form of its hydrochloride C₂₉H₄₁NO₄·HCl to control moderate to severe pain and treat opioid dependence

Note: Buprenorphine is administered by injection to control pain, is used in the form of a transdermal skin patch to control pain or treat opioid dependence, and is used in combination with naloxone in the form of a dissolvable tablet placed under the tongue or film placed inside the cheek to treat opioid dependence.

Examples of buprenorphine in a Sentence

Recent Examples on the Web

The test shows apparent negative results for the following substances: benzodiazepines, amphetamines, ecstasy, barbiturates, buprenorphine, cocaine, ketamine, methadone, meperidine, zolpidems, opiates, PCP, oxycodone, propoxyphene, cannabinoids, tramadol, ethanol, fentanyl and carisoprodol. —Marni Rose McFall, MSNBC Newsweek, 17 June 2025

Contributing factors were drowning, coronary artery disease and the effects of buprenorphine. —Edward Segarra, USA Today, 17 June 2025

An autopsy report also cited drowning, coronary artery disease and the effects of buprenorphine — a drug used to treat opioid use disorder — as contributing to his death. —Dominic Patten, Deadline, 16 June 2025

In a brain flooded simultaneously with buprenorphine and another opioid—the brain of a buprenorphine patient relapsing on fentanyl, for example—buprenorphine has dibs on the relevant receptors. —Ethan Brooks, The Atlantic, 23 Apr. 2025

Word History

First Known Use

1974, in the meaning defined above

Rhymes for buprenorphine

• acetylene
• adenosine
• amphetamine
• anthropocene
• antipyrine
• apomorphine
• apoprotein
• aquamarine
• arsphenamine
• azobenzene
• chlorobenzene
• chlorpromazine

Medical Definition

buprenorphine

noun

bu·​pre·​nor·​phine ˌbyü-prə-ˈnȯr-ˌfēn, -fən 

: a semisynthetic narcotic analgesic that is derived from thebaine and is administered in the form of its hydrochloride C₂₉H₄₁NO₄·HCl to control moderate to severe pain and treat opioid dependence

Note: Buprenorphine is administered by injection to control pain, is used in the form of a transdermal skin patch to control pain or treat opioid dependence, and is used in combination with naloxone in the form of a dissolvable tablet placed under the tongue or film placed inside the cheek to treat opioid dependence. Trademarks for preparations containing buprenorphine include Bunavail, Buprenex, Butrans, Subutex, Suboxone, and Zubsolv.