pain

1 :  to make suffer or cause distress to :  hurt

2 archaic :  to put (oneself) to trouble or exertion

1 archaic :  suffer

2 :  to give or have a sensation of pain

1 :  physical suffering that accompanies a bodily disorder (as a disease or an injury) The medicine relieves pain.

2 :  a very unpleasant feeling (as a prick or an ache) that is caused especially by something harmful I have a pain in my side.

3 :  suffering of the mind or emotions :  grief The humiliation brought her great pain.

4 pains plural :  great care or effort My sister took pains with the garden.

5 :  someone or something annoying

1 :  to cause physical or mental suffering in or to It pains me to think of it.

2 :  to give or feel physical or mental suffering The suckers, which were fastened to me and pained greatly, lessened their hold. — Scott O'Dell, Island of the Blue Dolphins

1a:  a state of physical, emotional, or mental lack of well-being or physical, emotional, or mental uneasiness that ranges from mild discomfort or dull distress to acute often unbearable agony, may be generalized or localized, and is the consequence of being injured or hurt physically or mentally or of some derangement of or lack of equilibrium in the physical or mental functions (as through disease), and that usually produces a reaction of wanting to avoid, escape, or destroy the causative factor and its effects was in constant painb:  a basic bodily sensation that is induced by a noxious stimulus, is received by naked nerve endings, is characterized by physical discomfort (as pricking, throbbing, or aching), and typically leads to evasive action

2pains plural :  the protracted series of involuntary contractions of the uterine musculature that constitute the major factor in parturient labor and that are often accompanied by considerable pain her pains had begun

:  to make suffer or cause distress to

1 :  punishment

2a :  physical discomfort associated with bodily disorder (as disease or injury) b :  acute mental or emotional suffering