painkiller

noun

pain·​kill·​er ˈpān-ˌki-lər 

variants or less commonly pain-killer

: something (such as a drug) that relieves pain

pain-killing

ˈpān-ˌki-liŋ 

adjective

or painkilling

Synonyms

• analgesic
• anesthetic
• anodyne

Examples of painkiller in a Sentence

I took some over-the-counter painkillers for my headache.

after her oral surgery, she was given a prescription for a mild painkiller

Recent Examples on the Web

Irsay worked his way up through the organization, learning how to run a football team, restoring the Colts’ once-proud tradition to glory and created what some have dubbed the greatest guitar collection on Earth — all while battling health issues and addictions to alcohol and painkillers. —Michael Marot, Chicago Tribune, 22 May 2025

Finch declined the painkillers prescribed by doctors. —Jon Krawczynski, New York Times, 20 May 2025

As the name suggests, the opioid signalling pathway in the brain is responsible for how opioids, like certain painkillers, act on the brain. —Eva Amsen, Forbes.com, 19 May 2025

Behind his calm exterior, Dante struggles with a painkiller habit and a lonely existence, softened only by the quiet company of his dog. —Anna Marie De La Fuente, Variety, 17 May 2025

Word History

First Known Use

1849, in the meaning defined above

Rhymes for painkiller

• basilar
• distiller
• biller
• chiller
• driller
• filler
• hilar
• hiller
• killer
• pillar
• quiller
• siller

Kids Definition

painkiller

noun

pain·​kill·​er ˈpān-ˌkil-ər 

: something (as a drug) that relieves pain

painkilling

-iŋ 

adjective

Medical Definition

painkiller

noun

pain·​kill·​er -ˌkil-ər 

: something (as a drug) that relieves pain

painkilling

-iŋ 

adjective