✨📕 The NEWThe NEW Collegiate Dictionary, 12th Edition Over 5,000 words added — Buy Now! Collegiate DictionaryBuy Now!

painkiller

noun

pain·​kill·​er ˈpān-ˌki-lər How to pronounce painkiller (audio)
variants or less commonly pain-killer
Synonyms of painkillernext
: something (such as a drug) that relieves pain
pain-killing adjective
or painkilling

Examples of painkiller in a Sentence

I took some over-the-counter painkillers for my headache. after her oral surgery, she was given a prescription for a mild painkiller
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
However, despite the popularity of marijuana as a painkiller, study results on its effectiveness have been mixed. Cnn.com Wire Service, Mercury News, 3 Dec. 2025 While painkillers like ibuprofen are often enough to relieve a headache, prescription medications are sometimes necessary to make head pain more bearable. Katherine Cobb-Pitstick, The Conversation, 1 Dec. 2025 Once returned to their usual environment, perhaps on painkillers, their demeanor can shift dramatically. Melissa Fleur Afshar, MSNBC Newsweek, 27 Nov. 2025 Many indigenous groups harnessed the plant as a painkiller, where it was used to treat everything from toothaches and sore throats to common colds and the flu. Caroline C. Boyle, USA Today, 21 Nov. 2025 See All Example Sentences for painkiller

Word History

First Known Use

1849, in the meaning defined above

Time Traveler
The first known use of painkiller was in 1849

Browse Nearby Words

Cite this Entry

“Painkiller.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/painkiller. Accessed 7 Dec. 2025.

Kids Definition

painkiller

noun
pain·​kill·​er ˈpān-ˌkil-ər How to pronounce painkiller (audio)
: something (as a drug) that relieves pain
painkilling adjective

Medical Definition

painkiller

noun
pain·​kill·​er -ˌkil-ər How to pronounce painkiller (audio)
: something (as a drug) that relieves pain
painkilling adjective

More from Merriam-Webster on painkiller

Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!