neu·​ro·​fi·​bro·​ma·​to·​sis ˌnu̇r-ō-(ˌ)fī-ˌbrō-mə-ˈtō-səs How to pronounce neurofibromatosis (audio)
: a disorder inherited as an autosomal dominant and characterized especially by brown spots on the skin, neurofibromas of peripheral nerves, and deformities of subcutaneous tissue and bone

Examples of neurofibromatosis in a Sentence

Recent Examples on the Web The 57-year-old has a rare form of neurofibromatosis, a genetic condition that causes growths to spread all over her nervous system. Eileen Finan, Peoplemag, 4 Feb. 2024 Soon after, a neurosurgeon diagnosed her with neurofibromatosis. Eileen Finan, Peoplemag, 4 Feb. 2024 Sebastian Stan plays Edward, an actor with the genetic condition known as neurofibromatosis, visualized here by large, fleshy facial prosthetics. Justin Chang, Los Angeles Times, 27 Jan. 2024 Pearson was diagnosed with neurofibromatosis, a rare genetic condition that leaves his skin covered in thousands of thick, painful tumors. Vanessa Etienne, Peoplemag, 22 Jan. 2024 Tumors caused by neurofibromatosis are most often benign but can become malignant, or cancerous, according to the Mayo Clinic. Sean Neumann, Peoplemag, 8 May 2023 The technology is expected to create more personalized health care for Henry Ford Health and neurofibromatosis patients. Detroit Free Press, 6 Sep. 2023 The Children’s Tumor Foundation has identified many such drug repositioning opportunities that could benefit patients with neurofibromatosis and schwannomatosis. Annette Bakker, STAT, 27 June 2023 Dwyane Wade Advocates for Trans Community and Daughter Zaya amid Anti-LGBT Legislation: 'Focus on Acceptance' Nick was diagnosed with neurofibromatosis (NF1) as a toddler. Sean Neumann, Peoplemag, 8 May 2023 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'neurofibromatosis.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


neurofibromat-, Greco-Latin stem of neurofibroma + -osis

First Known Use

1896, in the meaning defined above

Time Traveler
The first known use of neurofibromatosis was in 1896

Dictionary Entries Near neurofibromatosis

Cite this Entry

“Neurofibromatosis.” Dictionary, Merriam-Webster, Accessed 2 Mar. 2024.

Medical Definition


neu·​ro·​fi·​bro·​ma·​to·​sis -fī-ˌbrō-mə-ˈtō-səs How to pronounce neurofibromatosis (audio)
plural neurofibromatoses -ˌsēz How to pronounce neurofibromatosis (audio)
also neurofibromatosis type 1 or neurofibromatosis 1 : an inherited developmental disorder characterized especially by brown spots on the skin that are typically present at birth, neurofibromas of peripheral nerves, and deformities of subcutaneous tissues and bone
abbreviation NF, NF-1

called also Recklinghausen's disease, von Recklinghausen's disease

also neurofibromatosis type 2 or neurofibromatosis 2 : an inherited disorder characterized by bilateral acoustic neuromas developing in childhood or early adulthood that are typically accompanied by other nonmalignant tumors of the central nervous system
abbreviation NF, NF-2

Note: Both types of neurofibromatosis are inherited as an autosomal dominant trait requiring that one parent pass on a copy of the defective gene on a chromosome other than a sex chromosome. Type 1 is much more common than type 2.

More from Merriam-Webster on neurofibromatosis

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