neurofibromatosis

noun

neu·​ro·​fi·​bro·​ma·​to·​sis ˌnu̇r-ō-(ˌ)fī-ˌbrō-mə-ˈtō-səs 

ˌnyu̇r-

: a disorder inherited as an autosomal dominant and characterized especially by brown spots on the skin, neurofibromas of peripheral nerves, and deformities of subcutaneous tissue and bone

Examples of neurofibromatosis in a Sentence

Recent Examples on the Web

Generally, a developmental coordination disorder (DCD) diagnosis means that the symptoms are not part of a neurodevelopmental condition affecting the brain structure, such as cerebral palsy or neurofibromatosis. —Heidi Moawad, Verywell Health, 11 July 2024

In addition to neurofibromatosis, a key focus at the research building will be on closing the gap in health care outcomes for people based on race, ethnicity, gender and socioeconomic status. —Jc Reindl, Detroit Free Press, 18 June 2024

The run raises awareness of neurofibromatosis (NF) and fundraises for research through the Children's Tumor Foundation. —The Enquirer, 18 Feb. 2024

In May, Detroit businessman Dan Gilbert’s son, Nick, died after a long bout with neurofibromatosis, and several Detroit buildings lit up in green and blue, the colors of the ribbon that represents the campaign aimed at curing the disease. —Frank Witsil, Detroit Free Press, 25 Jan. 2024

Word History

Etymology

neurofibromat-, Greco-Latin stem of neurofibroma + -osis

First Known Use

1896, in the meaning defined above

Medical Definition

neurofibromatosis

noun

neu·​ro·​fi·​bro·​ma·​to·​sis -fī-ˌbrō-mə-ˈtō-səs 

plural neurofibromatoses -ˌsēz 

1

also neurofibromatosis type 1 or neurofibromatosis 1 : an inherited developmental disorder characterized especially by brown spots on the skin that are typically present at birth, neurofibromas of peripheral nerves, and deformities of subcutaneous tissues and bone

—abbreviation NF, NF-1

called also Recklinghausen's disease, von Recklinghausen's disease

2

also neurofibromatosis type 2 or neurofibromatosis 2 : an inherited disorder characterized by bilateral acoustic neuromas developing in childhood or early adulthood that are typically accompanied by other nonmalignant tumors of the central nervous system

—abbreviation NF, NF-2

Note: Both types of neurofibromatosis are inherited as an autosomal dominant trait requiring that one parent pass on a copy of the defective gene on a chromosome other than a sex chromosome. Type 1 is much more common than type 2.