Definition of neurofibromatosis
: a disorder inherited as an autosomal dominant and characterized especially by brown spots on the skin, neurofibromas of peripheral nerves, and deformities of subcutaneous tissue and bone
Origin and Etymology of neurofibromatosis
New Latin, from neurofibromat-, neurofibroma
First Known Use: 1896
Medical Definition of neurofibromatosis
1 also neurofibromatosis type 1 or neurofibromatosis 1 : an inherited developmental disorder characterized especially by brown spots on the skin that are typically present at birth, neurofibromas of peripheral nerves, and deformities of subcutaneous tissues and bone—abbreviation NF, NF-1; called also Recklinghausen's disease, von Recklinghausen's disease
2 also neurofibromatosis type 2 or neurofibromatosis 2 : an inherited disorder characterized by bilateral acoustic neuromas developing in childhood or early adulthood that are typically accompanied by other nonmalignant tumors of the central nervous system—abbreviation NF, NF-2 ◆Both types of neurofibromatosis are inherited as an autosomal dominant trait requiring that one parent pass on a copy of the defective gene on a chromosome other than a sex chromosome. Type 1 is much more common than type 2.
Learn More about neurofibromatosis
Britannica.com: Encyclopedia article about neurofibromatosis
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