neurofibromatosis

noun

neu·​ro·​fi·​bro·​ma·​to·​sis ˌnu̇r-ō-(ˌ)fī-ˌbrō-mə-ˈtō-səs 

ˌnyu̇r-

: a disorder inherited as an autosomal dominant and characterized especially by brown spots on the skin, neurofibromas of peripheral nerves, and deformities of subcutaneous tissue and bone

Examples of neurofibromatosis in a Sentence

Recent Examples on the Web

Summary There are three different types of neurofibromatosis: NF-1, NF-2, and schwannomatosis. —Brigid Dwyer, Verywell Health, 20 July 2024

This article describes neurofibromatosis types 1, 2, and 3. —Brigid Dwyer, Verywell Health, 20 July 2024

Edward’s newfound confidence wanes when, while out with drinks with his coworkers, he’s approached by Oswald (Adam Pearson), a charismatic man also born with neurofibromatosis. —Tatiana Tenreyro, The Hollywood Reporter, 16 July 2024

The film follows Edward, an aspiring actor with neurofibromatosis, a genetic condition that causes tumors to grow on the skin and bone. —Selena Kuznikov, Variety, 16 July 2024

Word History

Etymology

neurofibromat-, Greco-Latin stem of neurofibroma + -osis

First Known Use

1896, in the meaning defined above

Medical Definition

neurofibromatosis

noun

neu·​ro·​fi·​bro·​ma·​to·​sis -fī-ˌbrō-mə-ˈtō-səs 

plural neurofibromatoses -ˌsēz 

1

also neurofibromatosis type 1 or neurofibromatosis 1 : an inherited developmental disorder characterized especially by brown spots on the skin that are typically present at birth, neurofibromas of peripheral nerves, and deformities of subcutaneous tissues and bone

—abbreviation NF, NF-1

called also Recklinghausen's disease, von Recklinghausen's disease

2

also neurofibromatosis type 2 or neurofibromatosis 2 : an inherited disorder characterized by bilateral acoustic neuromas developing in childhood or early adulthood that are typically accompanied by other nonmalignant tumors of the central nervous system

—abbreviation NF, NF-2

Note: Both types of neurofibromatosis are inherited as an autosomal dominant trait requiring that one parent pass on a copy of the defective gene on a chromosome other than a sex chromosome. Type 1 is much more common than type 2.