agran·​u·​lo·​cy·​to·​sis ˌā-ˌgran-yə-lō-ˌsī-ˈtō-səs How to pronounce agranulocytosis (audio)
: an acute febrile condition marked by severe decrease in blood granulocytes and often associated with the use of certain drugs

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Example Sentences

Recent Examples on the Web To prevent and rapidly address cases of agranulocytosis, the FDA requires clozapine’s manufacturers to jointly administer the clozapine REMS program. Brian Barnett, STAT, 9 May 2022 Someone dying from a medication side effect is devastating, but the FDA’s singular focus on agranulocytosis is myopic. Brian Barnett, STAT, 9 May 2022 The drug may cause agranulocytosis, a dangerous lowering of white blood cells that puts patients at risk of serious infections, according to Berman., 29 Nov. 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'agranulocytosis.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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Word History


borrowed from German Agranulozytose, from a- a- entry 2 + Granulozyt granulocyte + -ose -osis

First Known Use

1922, in the meaning defined above

Time Traveler
The first known use of agranulocytosis was in 1922

Dictionary Entries Near agranulocytosis

Cite this Entry

“Agranulocytosis.” Dictionary, Merriam-Webster, Accessed 2 Oct. 2022.

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Medical Definition



agran·​u·​lo·​cy·​to·​sis ˌā-ˌgran-yə-lō-ˌsī-ˈtō-səs How to pronounce agranulocytosis (audio)
plural agranulocytoses -ˌsēz How to pronounce agranulocytosis (audio)
: an acute blood disorder that is marked by a decrease of circulating granulocytes (such as neutrophils) and is characterized especially by weakness, chills, swollen neck, sore throat, mouth ulcers, and jaundice

Note: Agranulocytosis results from a decline in the production of granulocytes or from granulocyte destruction. It is typically an acquired condition occurring as a side effect of certain drugs or chemotherapy or sometimes as a complication of various medical conditions (such as infection, autoimmune disease, or aplastic anemia).

called also agranulocytic angina, granulocytopenia

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