neurofibrillary tangle

noun

: a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease

Example Sentences

Recent Examples on the Web Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'neurofibrillary tangle.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

Word History

First Known Use

1963, in the meaning defined above

Time Traveler
The first known use of neurofibrillary tangle was in 1963

Dictionary Entries Near neurofibrillary tangle

Cite this Entry

“Neurofibrillary tangle.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/neurofibrillary%20tangle. Accessed 5 Feb. 2023.

Medical Definition

neurofibrillary tangle

noun
: a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of nerve cells of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease

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