neurofibrillary tangle

noun

Definition of neurofibrillary tangle

: a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease

Examples of neurofibrillary tangle in a Sentence

Recent Examples on the Web Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, "Blood Tests for Alzheimer’s: Two Experts on Why New Studies Are Encouraging," 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, "Blood Tests for Alzheimer’s: Two Experts on Why New Studies Are Encouraging," 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, "Blood Tests for Alzheimer’s: Two Experts on Why New Studies Are Encouraging," 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, "Blood Tests for Alzheimer’s: Two Experts on Why New Studies Are Encouraging," 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, "Blood Tests for Alzheimer’s: Two Experts on Why New Studies Are Encouraging," 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, "Blood Tests for Alzheimer’s: Two Experts on Why New Studies Are Encouraging," 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, "Blood Tests for Alzheimer’s: Two Experts on Why New Studies Are Encouraging," 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, "Blood Tests for Alzheimer’s: Two Experts on Why New Studies Are Encouraging," 13 Aug. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'neurofibrillary tangle.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

See More

First Known Use of neurofibrillary tangle

1963, in the meaning defined above

Keep scrolling for more

Learn More about neurofibrillary tangle

Time Traveler for neurofibrillary tangle

Time Traveler

The first known use of neurofibrillary tangle was in 1963

See more words from the same year

Statistics for neurofibrillary tangle

Cite this Entry

“Neurofibrillary tangle.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/neurofibrillary%20tangle. Accessed 28 Oct. 2020.

Keep scrolling for more

More Definitions for neurofibrillary tangle

neurofibrillary tangle

noun

Medical Definition of neurofibrillary tangle

: a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of nerve cells of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease

More from Merriam-Webster on neurofibrillary tangle

Britannica.com: Encyclopedia article about neurofibrillary tangle

Comments on neurofibrillary tangle

What made you want to look up neurofibrillary tangle? Please tell us where you read or heard it (including the quote, if possible).

WORD OF THE DAY

Test Your Vocabulary

Namesakes Word Quiz

  • a citrus fruit possibly named after a person
  • Which of the following is a fruit named after a Moroccan seaport?
Spell It

Can you spell these 10 commonly misspelled words?

TAKE THE QUIZ
Dictionary Devil

Test Your Knowledge - and learn some interesting things along the way.

TAKE THE QUIZ
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!