neurofibrillary tangle

noun

Definition of neurofibrillary tangle

: a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease

Examples of neurofibrillary tangle in a Sentence

Recent Examples on the Web Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019 Those two lesions are beta-amyloid plaques and neurofibrillary tangles. Scientific American, 13 Aug. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'neurofibrillary tangle.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of neurofibrillary tangle

1963, in the meaning defined above

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The first known use of neurofibrillary tangle was in 1963

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Dictionary Entries Near neurofibrillary tangle

neurofibril

neurofibrillary tangle

neurofibroma

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Cite this Entry

“Neurofibrillary tangle.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/neurofibrillary%20tangle. Accessed 16 Oct. 2021.

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More Definitions for neurofibrillary tangle

neurofibrillary tangle

noun

Medical Definition of neurofibrillary tangle

: a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of nerve cells of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease

More from Merriam-Webster on neurofibrillary tangle

Britannica.com: Encyclopedia article about neurofibrillary tangle

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