neurofibrillary tangle

noun

Definition of neurofibrillary tangle

:a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of neurons of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease

First Known Use of neurofibrillary tangle

1963


Medical Dictionary

neurofibrillary tangle

noun

medical Definition of neurofibrillary tangle

:a pathological accumulation of paired helical filaments composed of abnormally formed tau protein that is found chiefly in the cytoplasm of nerve cells of the brain and especially the cerebral cortex and hippocampus and that occurs typically in Alzheimer's disease

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