neurodegenerative

adjective

neu·​ro·​de·​gen·​er·​a·​tive ˌnu̇r-ō-di-ˈje-nə-rə-tiv 

-ˈjen-rə-;

-ˈje-nə-ˌrā-;

-dē-, 

ˌnyu̇r-

: relating to or marked by degeneration of nervous tissue

Examples of neurodegenerative in a Sentence

Recent Examples on the Web

Lauren Holder is an advocate for the Huntington’s disease community who is also living with the early stages of the progressive and fatal neurodegenerative condition. — Adam Feuerstein, STAT, 1 Oct. 2026

According to the American Brain Foundation, frontotemporal degeneration (also known as frontotemporal dementia), is a group of neurodegenerative disorders associated with changes in the brain’s frontal and temporal lobes. — Zach Dean Outkick, FOXNews.com, 24 Sep. 2026

Among the people who had donated their brains to research, nearly 60% had been diagnosed with dementia, while just under 19% had a neurodegenerative condition listed as a cause of death. — Mike McRae 15, New Atlas, 15 Sep. 2026

New research released in the journal BMJ reveals that 1 in 4 former NFL players in this sample had CTE, a neurodegenerative brain disease caused by repetitive head injuries. — Rebecca Ramirez, NPR, 31 Aug. 2026

Word History

First Known Use

1907, in the meaning defined above

Phrases Containing neurodegenerative

• neurodegenerative disease
• neurodegenerative disorder

Rhymes for neurodegenerative

• degenerative
• regenerative
• generative

Medical Definition

neurodegenerative

adjective

neu·​ro·​de·​gen·​er·​a·​tive -di-ˈjen-ə-ˌrāt-iv, -di-ˈjen-(ə-)rət- 

: relating to or characterized by degeneration of nervous tissue

neurodegeneration

-di-ˌjen-ə-ˈrā-shən, -ˌdē- 

noun