degenerative

adjective

de·​gen·​er·​a·​tive di-ˈje-nə-rə-tiv 

-ˈjen-rə-;

-ˈje-nə-ˌrā-;

dē-

: of, relating to, involving, or causing degeneration

a degenerative disease

Did you know?

Degenerative diseases—including cancer, glaucoma, Parkinson's, diabetes, arthritis, and leprosy—are usually contrasted with infectious diseases (diseases caused by bacteria, viruses, fungi, and protozoa). However, many infectious diseases (Lyme disease, AIDS, etc.) can cause a body or body part to degenerate, and infective organisms play a part in some degenerative diseases. Some degenerative diseases can be controlled; some can even be cured. But no one has yet discovered a way to reverse such degenerative conditions as multiple sclerosis, emphysema, or Alzheimer's.

Examples of degenerative in a Sentence

Recent Examples on the Web

Former Dallas Cowboys defensive end Marshawn Kneeland was found to have stage 1 of the degenerative brain disease CTE after a posthumous exam by Boston University researchers. — Lawrence Dow, Fort Worth Star-Telegram, 7 July 2026

Given that Stafford is 38 and managing a degenerative back issue, this has become the primary question for a team currently favored to win the Super Bowl. — The Athletic Nfl Staff, New York Times, 30 June 2026

Chris Johnson, the former NFL running back who holds the record for most yards from scrimmage in a single season, has the degenerative neurological disorder amyotrophic lateral sclerosis, commonly known as ALS or Lou Gehrig’s disease. — Chuck Schilken, Los Angeles Times, 29 June 2026

Roberts is requesting five years of probation, citing her clean 50-year record, age and health conditions including diabetes and a degenerative spine condition. — Sofi Zeman, Kansas City Star, 24 June 2026

Word History

First Known Use

circa 1680, in the meaning defined above

Rhymes for degenerative

• regenerative
• generative
• neurodegenerative

Kids Definition

degenerative

adjective

de·​gen·​er·​a·​tive di-ˈjen-ə-ˌrāt-iv 

-ˈjen-(ə-)rət-iv

: of, relating to, or tending to cause degeneration

a degenerative disease

Medical Definition

degenerative

adjective

de·​gen·​er·​a·​tive di-ˈjen-ə-ˌrāt-iv  -ˈjen-(ə-)rət- 

: of, relating to, involving, or tending to cause degeneration

degenerative conditions of the nervous system

—Morris Fishbein

degenerative changes

a degenerative muscle disorder