Definition of multisystem
: relating to, involving, or consisting of two or more systems
… the proliferation of PCs and workstations on desktops, benchtops, and factory floors, has made multisystem communications a way of organizational life.— Ralph Emmett Carlyle
specifically
: involving or affecting more than one system of bodily organs
… a multisystem disorder that most commonly involves the lung and skin but can also present with ear, nose, and throat (ENT) involvement as well as involvement of the cardiovascular, renal, gastrointestinal, and central nervous systems. — Sruthi Renati B. S. et al. … patients often have multisystem injuries that complicate aortic repair. — David G. Neschis
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Merriam-Webster unabridged
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Time Traveler for multisystem
The first known use of multisystem was in 1950
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