mul·​ti·​sys·​tem ˈməl-tē-ˌsi-stəm How to pronounce multisystem (audio)
: relating to, involving, or consisting of two or more systems
… the proliferation of PCs and workstations on desktops, benchtops, and factory floors, has made multisystem communications a way of organizational life.Ralph Emmett Carlyle
specifically : involving or affecting more than one system of bodily organs
… a multisystem disorder that most commonly involves the lung and skin but can also present with ear, nose, and throat (ENT) involvement as well as involvement of the cardiovascular, renal, gastrointestinal, and central nervous systems. Sruthi Renati B. S. et al.
… patients often have multisystem injuries that complicate aortic repair. David G. Neschis

Word History

First Known Use

1950, in the meaning defined above

Time Traveler
The first known use of multisystem was in 1950

Cite this Entry

“Multisystem.” Dictionary, Merriam-Webster, Accessed 3 Mar. 2024.

Medical Definition


mul·​ti·​sys·​tem -ˌsis-təm How to pronounce multisystem (audio)
variants also multi-system or multisystemic
: relating to, involving, or affecting more than one bodily system
systemic lupus erythematosus is a multisystem disease
died of multisystem organ failure
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