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                                                      : an indefinite feeling of debility or lack of health often indicative of or accompanying the onset of an illness                                      
              
                             
An infected person will feel a general malaise.
                         
                
                    2
                    
                                          
              
          
                                                      : a vague sense of mental or moral ill-being                                      
              
                             
a malaise of cynicism and despair— Malcolm Boyd
Malcolm Boyd
                         
                
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  Merriam-Webster unabridged




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