major depressive disorder


Definition of major depressive disorder 

: a mood disorder having a clinical course involving one or more episodes of serious psychological depression lasting two or more weeks each with no intervening episodes of mania

Examples of major depressive disorder in a Sentence

Recent Examples on the Web

Marshall said his wife suffered major depressive disorder and anxiety. CBS News, "Alabama Attorney General Steve Marshall recalls final call with wife before her suicide," 29 June 2018 He was admitted to Wentworth in October 2016, with diagnoses of major depressive disorder, cocaine use and lung disease, reports state. Sam Roe,, "Inside Chicago's worst nursing home: bug bites, bruises and death," 13 June 2018 Her son, Kurt Skelley, took his own life in 2014 after struggling with major depressive disorder, a form of depression. Hayley Harding,, "Memorial Lacrosse Game Saturday To Honor Life Of Avon Grad," 14 June 2018 According to the findings, published June 22 in Science, conditions such as schizophrenia, major depressive disorder (MDD) and bipolar disorder share a suite of overlapping genetic variants rather than having distinct genetic signatures. Emily Willingham, Scientific American, "Analysis of a Million-Plus Genomes Points to Blurring Lines Among Brain Disorders," 22 June 2018 Doctors diagnosed him with generalized anxiety disorder, major depressive disorder and disruptive mood dysregulation disorder, according to the documents. Vikki Ortiz,, "CPS students denied special education services amid 'cycle of chaos,' parents say," 19 June 2018 Treatment for persistent and major depressive disorder is similar, but some experts view PDD as being harder to tame. Christina Stiehl, SELF, "The Difference Between Depression and Persistent Depressive Disorder, aka Dysthymia," 4 May 2018 If clinical trials are positive, the FDA will allow Sage to seek approval for SAGE-217 to treat major depressive disorder and postpartum depression faster than previously expected. Adam Feuerstein, STAT, "Sage Therapeutics gets ‘go faster’ permission from FDA on oral depression drug," 12 June 2018 The results of the study concluded that neither gender nor economic status seemed to increase the likelihood of major depressive disorders in African-American youths. Michael Harriot, The Root, "Study: Affluent Black Kids Suffer Higher Rates of Depression Because ... You Guessed It: Racism," 15 May 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'major depressive disorder.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of major depressive disorder

1978, in the meaning defined above

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The first known use of major depressive disorder was in 1978

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major depressive disorder


Medical Definition of major depressive disorder 

: a mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts — compare bipolar disorder

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exaggeratedly or childishly emotional

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