major depressive disorder


Definition of major depressive disorder

: a mood disorder having a clinical course involving one or more episodes of serious psychological depression lasting two or more weeks each with no intervening episodes of mania

Examples of major depressive disorder in a Sentence

Recent Examples on the Web

The form of depression, also known as SAD, is a recurrent major depressive disorder that involves episodes of depression at the same season each year. Maya Mcdowell, House Beautiful, "8 Ways to Feel Happier at Home When Winter’s Bringing You Down," 15 Feb. 2019 Silverman explains that in the DSM-5, experts essentially collapsed two mood disorders—chronic major depressive disorder and dysthymia—into one: PDD. Claire Gillespie, SELF, "What Exactly Does It Mean to Have ‘High-Functioning’ Depression?," 19 Nov. 2018 Shiloh medical staff diagnosed Lucas with major depressive disorder and told him that officials would not release him until Shiloh medical personnel declared him psychologically sound. Samantha Schmidt, The Seattle Times, "Trump administration must stop giving psychotropic drugs to migrant children without consent, judge rules," 31 July 2018 Over the next decade, researchers continued to explore its potential as a treatment for major depressive disorder. Alice Levitt, Vox, "I tried ketamine to treat my depression. Within a day, I felt relief.," 24 July 2018 Marshall said his wife suffered major depressive disorder and anxiety. CBS News, "Alabama Attorney General Steve Marshall recalls final call with wife before her suicide," 29 June 2018 He was admitted to Wentworth in October 2016, with diagnoses of major depressive disorder, cocaine use and lung disease, reports state. Sam Roe,, "Inside Chicago's worst nursing home: bug bites, bruises and death," 13 June 2018 Her son, Kurt Skelley, took his own life in 2014 after struggling with major depressive disorder, a form of depression. Hayley Harding,, "Memorial Lacrosse Game Saturday To Honor Life Of Avon Grad," 14 June 2018 According to the findings, published June 22 in Science, conditions such as schizophrenia, major depressive disorder (MDD) and bipolar disorder share a suite of overlapping genetic variants rather than having distinct genetic signatures. Emily Willingham, Scientific American, "Analysis of a Million-Plus Genomes Points to Blurring Lines Among Brain Disorders," 22 June 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'major depressive disorder.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of major depressive disorder

1978, in the meaning defined above

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Statistics for major depressive disorder

Last Updated

24 Feb 2019

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The first known use of major depressive disorder was in 1978

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major depressive disorder


Medical Definition of major depressive disorder

: a mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts — compare bipolar disorder

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