major depressive disorder

noun

Definition of major depressive disorder

: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : clinical depression, major depression About 18 million Americans are diagnosed with a major depressive disorder each year.— David Schwab The most serious form of depression is major depressive disorder, characterized by depressed mood, loss of interest or pleasure, changes in appetite, increased or decreased sleep, increased or decreased motor activity, fatigue, feelings of worthlessness or guilt, difficulty concentrating and, for some people, recurrent thoughts of death or suicide.— Sandi Lloyd abbreviation MDD

Examples of major depressive disorder in a Sentence

Recent Examples on the Web These therapeutics are being investigated for treating conditions, such as major depressive disorder, severe anxiety, and substance abuse. Joshua Cohen, Forbes, 5 July 2021 In fact, treatment for actual major depressive disorder has about a 65% effective rate, and the remaining 35% just suffer through life until their depression kills them by suicide or disease brought on by the stress and anxiety of depression. Annie Lane, oregonlive, 8 June 2021 Timeline June 17, 1999 - Overdoses on Trazodone, a medication used to treat depression, and is admitted to Methodist Hospital psychiatric unit where she is diagnosed with a major depressive disorder. Cnn Editorial Research, CNN, 20 June 2021 Cybin, which went public on Toronto’s NEO Exchange through a reverse takeover of a mining company in 2019, plans to bring its dissolvable oral strip dosed with psilocybin to market to help treat major depressive disorder when coupled with therapy. Will Yakowicz, Forbes, 20 May 2021 In August of last year, the FDA extended its approval for esketamine to adults with major depressive disorder with acute suicidal ideation or behavior. Joshua Cohen, Forbes, 5 July 2021 Cybin will launch a phase two clinical trial to study its sublingual formulation of psilocybin for patients with major depressive disorder at the University of the West Indies Hospital in Jamaica later this year. Will Yakowicz, Forbes, 24 June 2021 Proceeds go to the nonprofit alliance to help San Diego County residents with brain disorders, ranging from schizophrenia and bipolar disorder to major depressive disorder. Linda Mcintosh, San Diego Union-Tribune, 23 June 2021 Even when studying diseases that affect more women than men, like Alzheimer’s disease, major depressive disorder or stroke, scientists more often than not chose to work exclusively with males. Rebecca M. Shansky, Scientific American, 1 June 2021

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'major depressive disorder.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of major depressive disorder

1977, in the meaning defined above

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The first known use of major depressive disorder was in 1977

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major depression

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major diameter

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Last Updated

6 Sep 2021

Cite this Entry

“Major depressive disorder.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/major%20depressive%20disorder. Accessed 24 Sep. 2021.

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More Definitions for major depressive disorder

major depressive disorder

noun

Medical Definition of major depressive disorder

: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, or feelings of worthlessness or guilt : clinical depression, major depression The diagnosis of both major depressive disorder and subsyndromal symptoms is complicated by difficulties that elderly patients may have in recognizing or describing depressive symptoms.— Lawrence M. Martin et al., The John Hopkins White Papers abbreviation MDD

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