major depressive disorder

noun

: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : clinical depression, major depression
About 18 million Americans are diagnosed with a major depressive disorder each year. David Schwab
The most serious form of depression is major depressive disorder, characterized by depressed mood, loss of interest or pleasure, changes in appetite, increased or decreased sleep, increased or decreased motor activity, fatigue, feelings of worthlessness or guilt, difficulty concentrating and, for some people, recurrent thoughts of death or suicide. Sandi Lloyd
abbreviation MDD

Example Sentences

Recent Examples on the Web But Jackson had other symptoms—like being unfocused at work, feeling down most days, and not having much of an appetite—that led me to diagnose him with major depressive disorder and prescribe an antidepressant. Gregory Scott Brown, Men's Health, 10 Nov. 2022 In a 2021 study, more than half of American adults reported symptoms of major depressive disorder after a coronavirus infection. Knvul Sheikh, BostonGlobe.com, 12 Nov. 2022 Each hour that a person can move earlier the midpoint of their nightly sleep cycle is associated with a 23% lower risk of major depressive disorder, according to the JAMA psychiatry study. Alex Janin, WSJ, 4 Nov. 2022 Researchers found that people who walked 4 miles a day — about 8,200 steps — were less likely to become obese or suffer from sleep apnea, acid reflux and major depressive disorder. Sandee Lamotte, CNN, 10 Oct. 2022 The company is working on digital therapeutics to improve attention and cognitive dysfunction in several additional neuropsychiatric diseases, including autism spectrum disorder, major depressive disorder, and multiple sclerosis. Ryan Cross, BostonGlobe.com, 19 Aug. 2022 One study from the Chongqing Medical University in China found that the gut microbiomes of people diagnosed with major depressive disorder were very different from those of the general population. Laura Newberry, Los Angeles Times, 13 Sep. 2022 The drug, a once-daily oral treatment known as PRAX-114, missed its primary and secondary goals in a study enrolling about 200 patients with major depressive disorder. Damian Garde, STAT, 8 June 2022 And a study by the American Heart Association found that a diagnosis of major depressive disorder was associated with an average of 27 lost work days annually per employee, costing employers $4,426 a year. Georgina Miranda, Outside Online, 25 Aug. 2021 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'major depressive disorder.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

Word History

First Known Use

1977, in the meaning defined above

Time Traveler
The first known use of major depressive disorder was in 1977

Dictionary Entries Near major depressive disorder

Cite this Entry

“Major depressive disorder.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/major%20depressive%20disorder. Accessed 2 Dec. 2022.

Medical Definition

major depressive disorder

noun

: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : clinical depression, major depression
The diagnosis of both major depressive disorder and subsyndromal symptoms is complicated by difficulties that elderly patients may have in recognizing or describing depressive symptoms. Lawrence M. Martin et al., The John Hopkins White Papers
abbreviation MDD
Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!


Words Named After People

  • name tags
  • Namesake of the leotard, Jules Léotard had what profession?
True or False

Test your knowledge - and maybe learn something along the way.

TAKE THE QUIZ
Universal Daily Crossword

A daily challenge for crossword fanatics.

TAKE THE QUIZ