major depressive disorder

noun

: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : clinical depression, major depression
About 18 million Americans are diagnosed with a major depressive disorder each year.David Schwab
The most serious form of depression is major depressive disorder, characterized by depressed mood, loss of interest or pleasure, changes in appetite, increased or decreased sleep, increased or decreased motor activity, fatigue, feelings of worthlessness or guilt, difficulty concentrating and, for some people, recurrent thoughts of death or suicide.Sandi Lloyd
abbreviation MDD

Examples of major depressive disorder in a Sentence

Recent Examples on the Web Mark Patterson, a psychologist whom Patel’s attorney called to the witness stand last month, testified that Patel appeared to be experiencing major depressive disorder that day, along with psychotic features and anxious distress. Jakob Rodgers, The Mercury News, 2 May 2024 This week, the FDA cleared the first prescription digital treatment for major depressive disorder. Alexandra Banner, CNN, 3 Apr. 2024 The Food and Drug Administration has cleared Otsuka Pharmaceutical’s digital treatment for major depressive disorder, offering a new option for millions of people who struggle with the stubborn mental health condition. Mario Aguilar, STAT, 1 Apr. 2024 Studies have found that some 50% to 70% of patients with major depressive disorder see their symptoms improve after a course of ECT. Elizabeth Landau, Quanta Magazine, 18 Mar. 2024 Twenty-three people in the study had PTSD, half met the criteria for having a major depressive disorder and 14 had an anxiety disorder. Eduardo Cuevas, USA TODAY, 5 Jan. 2024 In 2019, the Food and Drug Administration bestowed breakthrough status—essentially, speeding up the drug development and review process—on psilocybin therapy for major depressive disorder and treatment-resistant depression. Daliah Singer, Smithsonian Magazine, 17 Nov. 2023 The doctors were given one of two case studies: the first, about a patient with borderline personality disorder; the other, about a patient with major depressive disorder. Katie Engelhart, New York Times, 3 Jan. 2024 The device will target the prefrontal cortex, which is impaired in patients with major depressive disorder. Emily Mullin, WIRED, 23 Dec. 2023

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'major depressive disorder.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1977, in the meaning defined above

Time Traveler
The first known use of major depressive disorder was in 1977

Dictionary Entries Near major depressive disorder

Cite this Entry

“Major depressive disorder.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/major%20depressive%20disorder. Accessed 22 May. 2024.

Medical Definition

major depressive disorder

noun
: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : clinical depression, major depression
The diagnosis of both major depressive disorder and subsyndromal symptoms is complicated by difficulties that elderly patients may have in recognizing or describing depressive symptoms.Lawrence M. Martin et al., The John Hopkins White Papers
abbreviation MDD
Last Updated: - Updated example sentences
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