major depressive disorder


Definition of major depressive disorder

: a mood disorder having a clinical course involving one or more episodes of serious psychological depression lasting two or more weeks each with no intervening episodes of mania

Examples of major depressive disorder in a Sentence

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Other work used donated tissue to look at the genes associated with major depressive disorder. Emily Toomey, Smithsonian, "Inside a Brain Bank, Where Humans’ Most Precious Organ Is Dissected and Studied," 21 Aug. 2019 The UC Irvine Institute for Interdisciplinary Salivary Bioscience Research recently received a $1-million donation to expand a study that uses saliva to monitor lithium levels in patients with bipolar and major depressive disorders. Daily Pilot Staff,, "Around Town: OC Brew Hee Haw brings beer and music to fair," 11 July 2019 Tindell said his client suffers from major depressive disorder., "Gresham man who fatally injured girlfriend, waited 18 hours to bring her to hospital, gets 15 years in prison," 10 July 2019 Private claims for anxiety, post-traumatic stress disorder, major depressive disorder and bipolar disorder all increased by 65 percent or more, individually. Jared Weber, USA TODAY, "San Francisco proposes nation’s first universal mental health care system," 4 June 2019 The drug is specifically approved for people with major depressive disorder who have tried at least two antidepressants and haven’t responded to treatment (known as treatment-resistant depression), the FDA said in a press announcement. Korin Miller, SELF, "What You Need to Know About Esketamine, the First Nasal Spray Approved to Treat Depression," 7 Mar. 2019 The form of depression, also known as SAD, is a recurrent major depressive disorder that involves episodes of depression at the same season each year. Maya Mcdowell, House Beautiful, "8 Ways to Feel Happier at Home When Winter’s Bringing You Down," 15 Feb. 2019 Silverman explains that in the DSM-5, experts essentially collapsed two mood disorders—chronic major depressive disorder and dysthymia—into one: PDD. Claire Gillespie, SELF, "What Exactly Does It Mean to Have ‘High-Functioning’ Depression?," 19 Nov. 2018 Shiloh medical staff diagnosed Lucas with major depressive disorder and told him that officials would not release him until Shiloh medical personnel declared him psychologically sound. Samantha Schmidt, The Seattle Times, "Trump administration must stop giving psychotropic drugs to migrant children without consent, judge rules," 31 July 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'major depressive disorder.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of major depressive disorder

1978, in the meaning defined above

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Last Updated

25 Aug 2019

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The first known use of major depressive disorder was in 1978

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major depressive disorder


Medical Definition of major depressive disorder

: a mood disorder having a clinical course involving one or more episodes of serious psychological depression that last two or more weeks each, do not have intervening episodes of mania or hypomania, and are characterized by a loss of interest or pleasure in almost all activities and by some or all of disturbances of appetite, sleep, or psychomotor functioning, a decrease in energy, difficulties in thinking or making decisions, loss of self-esteem or feelings of guilt, and suicidal thoughts or attempts — compare bipolar disorder

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one from the Upper Peninsula of Michigan

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