major depression

noun

Definition of major depression

: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : clinical depression, major depressive disorder Episodes of major depression usually last several months and may recur throughout a lifetime.The Harvard Mental Health Letter Psychiatrists have found that among distinguished artists, the rates of manic depression and major depression are 10 to 30 times as prevalent as in the population at large.— Natalie Angier

Examples of major depression in a Sentence

Recent Examples on the Web Though not currently considered a diagnosis in the Diagnostic and Statistical Manual of Mental Disorders (DSM-V), it is listed as a symptom of various anxiety disorders, major depression and post-traumatic stress disorder. John Duffy, CNN, 23 Aug. 2021 But it has long been approved as an anesthesia drug in kids and adults, and researchers were finalizing its approval as a treatment for major depression. Katie Palmer, STAT, 5 Aug. 2021 Our adoptive father was abusive, and our mother had her own share of issues stemming from major depression. Annie Lane, oregonlive, 16 June 2021 In up to a third of patients with major depression, standard medications that block receptors for the key neurotransmitters, serotonin and norepinephrine, are not effective. Robert Glatter, Forbes, 10 June 2021 Our adoptive father was abusive, and our mother had her own share of issues stemming from major depression. cleveland, 1 June 2021 Johns Hopkins published results in JAMA Psychiatry last year, where more than half the 24 people with major depression who had two psilocybin sessions (along with supportive psychotherapy) were in remission a month later. Meryl Davids Landau, Good Housekeeping, 10 June 2021 Until recently, major depression has felt like a ghost disease–invisible but devastating. Susanna Schrobsdorff, Time, 17 May 2021 One study examining survivors of 10 disasters found that one-third had a post-disaster diagnosis — with post-traumatic stress disorder being the most prevalent (20%), followed by major depression (16%) and alcohol use disorder (9%). Los Angeles Times, 11 June 2021

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'major depression.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of major depression

1977, in the meaning defined above

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The first known use of major depression was in 1977

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Dictionary Entries Near major depression

major canon

major depression

major depressive disorder

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Statistics for major depression

Last Updated

5 Sep 2021

Cite this Entry

“Major depression.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/major%20depression. Accessed 24 Sep. 2021.

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More Definitions for major depression

major depression

noun

Medical Definition of major depression

: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, or feelings of worthlessness or guilt : clinical depression, major depressive disorder

More from Merriam-Webster on major depression

Britannica.com: Encyclopedia article about major depression

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