major depression

noun

: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : clinical depression, major depressive disorder
Episodes of major depression usually last several months and may recur throughout a lifetime.The Harvard Mental Health Letter
Psychiatrists have found that among distinguished artists, the rates of manic depression and major depression are 10 to 30 times as prevalent as in the population at large.Natalie Angier

Examples of major depression in a Sentence

Recent Examples on the Web According to Our World in Data, one in three women and one in five men will experience major depression in their lifetime. Kyle Russell, USA TODAY, 5 Jan. 2024 In the weeks that followed, she was correctly diagnosed with ADHD, post-traumatic stress disorder and major depression — after being misdiagnosed as a teenager with schizophrenia. Angela Roberts, Hartford Courant, 13 Jan. 2024 Sage had asked regulators to approve the drug as a treatment for both postpartum and major depression, the latter of which has a much larger sales potential. Allison Deangelis Reprints, STAT, 8 Jan. 2024 Several prior studies have suggested that psilocybin, the psychedelic compound produced by certain types of mushrooms, could be a promising way to treat major depression in people for whom antidepressants or counseling aren’t effective. Annalisa Merelli, STAT, 31 Aug. 2023 At eight weeks postpartum, mothers who exhibit symptoms of major depression are more likely than other mothers to report that their babies wake three times or more each night. Sarah Twombly, The Atlantic, 2 Nov. 2023 The study, with 403 participants, was significantly larger than previous ketamine comparison studies; a meta-analysis of these smaller studies, published last year and focused on major depression rather than treatment-resistant depression, found ECT had better results. Olivia Goldhill, STAT, 24 May 2023 Super, 59, has been open about her struggle with major depression, an issue she’s written about. Judith Graham, Fortune Well, 28 Nov. 2023 According to the Centers for Disease Control and Prevention, around 30 percent of those with epilepsy also suffer from serious mental health illnesses, including bipolar disorder, major depression and schizophrenia. Sara Novak, Discover Magazine, 10 May 2023

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'major depression.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1977, in the meaning defined above

Time Traveler
The first known use of major depression was in 1977

Dictionary Entries Near major depression

Cite this Entry

“Major depression.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/major%20depression. Accessed 17 Apr. 2024.

Medical Definition

major depression

noun
: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : clinical depression, major depressive disorder

More from Merriam-Webster on major depression

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