major depression

noun

: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : clinical depression, major depressive disorder
Episodes of major depression usually last several months and may recur throughout a lifetime. The Harvard Mental Health Letter
Psychiatrists have found that among distinguished artists, the rates of manic depression and major depression are 10 to 30 times as prevalent as in the population at large. Natalie Angier

Example Sentences

Recent Examples on the Web Since the late ’90s, Kathy Wallace has been battling major depression with a series of drugs — first Prozac, then three others, and back again to Prozac. Katie Palmer Reprints, STAT, 5 Nov. 2022 The voices could also be a sign of other mental illnesses, such as post-traumatic stress disorder, anxiety, major depression or even obsessive-compulsive disorder. Meghan Leahy, Washington Post, 24 Aug. 2022 After conducting a survey from 2019 to 2020, the researchers estimated that in the year before the survey, about one in five Flint residents presumptively experienced major depression, while a quarter had PTSD, and one in 10 had both illnesses. Time, 22 Sep. 2022 About 40 million adults over 18 in the United States live with an anxiety disorder, while over 21 million have suffered from major depression, according to national statistics. Sandee Lamotte, CNN, 18 Sep. 2022 Using light to treat SAD, as well as non-seasonal major depression, postpartum depression, and even bipolar disorder has proven extremely effective in the past. Joshua Hawkins, BGR, 20 Sep. 2022 According to the National Institute of Mental Health, of the three million American adolescents who experienced major depression in 2020, almost two-thirds received no treatment. Andrew Solomon, The New Yorker, 4 Apr. 2022 The drug, to be sold as Auvelity, had a rapid and significant effect on major depression in a roughly 300-patient trial, outperforming placebo on a measure of depression symptoms after one week and sustaining the effect for another five. Damian Garde, STAT, 22 Aug. 2022 Other studies have shown active or indirect participation in protests can result in a substantial increase in anxiety, major depression and post-traumatic stress disorder, researchers said. oregonlive, 28 Apr. 2021 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'major depression.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

Word History

First Known Use

1977, in the meaning defined above

Time Traveler
The first known use of major depression was in 1977

Dictionary Entries Near major depression

Cite this Entry

“Major depression.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/major%20depression. Accessed 27 Nov. 2022.

Medical Definition

major depression

noun

: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : clinical depression, major depressive disorder

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