major depression

noun

: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : clinical depression, major depressive disorder
Episodes of major depression usually last several months and may recur throughout a lifetime.The Harvard Mental Health Letter
Psychiatrists have found that among distinguished artists, the rates of manic depression and major depression are 10 to 30 times as prevalent as in the population at large.Natalie Angier

Examples of major depression in a Sentence

Recent Examples on the Web The psychological effects of chronic acne are devastating and can cause major depression – something that the two co-founders of ClearStem care deeply about. WWD, 2 July 2024 Research has shown that 25% of people with lupus have major depression, and 37% have anxiety.11 Body image is often an important issue for people with lupus. Serenity Mirabito, Rn, Health, 19 June 2024 These programs could offer new therapeutic avenues for treating persistent cycles of negative thoughts in patients with major depression or the chronic worrying that characterizes generalized anxiety disorder. Matthew D. Sacchet, Scientific American, 25 June 2024 It’s estimated that one-in-three women and one-in-five men have an episode of major depression by the age of 65. Big Think, 24 June 2024 See all Example Sentences for major depression 

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'major depression.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1977, in the meaning defined above

Time Traveler
The first known use of major depression was in 1977

Dictionary Entries Near major depression

Cite this Entry

“Major depression.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/major%20depression. Accessed 21 Jul. 2024.

Medical Definition

major depression

noun
: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : clinical depression, major depressive disorder

More from Merriam-Webster on major depression

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