mac·​ro·​mol·​e·​cule ˌma-krō-ˈmä-li-ˌkyü(ə)l How to pronounce macromolecule (audio)
: a very large molecule (as of a protein or rubber)
macromolecular adjective

Examples of macromolecule in a Sentence

Recent Examples on the Web Studying cell division requires simultaneously viewing nanometer-scale macromolecules like proteins and DNA all the way up to millimeter-scale populations of cells, and over a time frame that ranges from seconds to weeks. Somin Lee, The Conversation, 20 July 2023 Last year, the Curiosity rover identified two sites flush with complex organic macromolecules that resemble the goopy building blocks of oil on Earth. Daniel Clery, Science | AAAS, 21 Nov. 2019 Quantum theory works extremely well at the scale of photons, electrons, atoms, molecules, even macromolecules. Wired, 9 Dec. 2018 Last year, the Nobel Prize in Chemistry was given in part to Frances H. Arnold, who for decades has been studying macromolecules known as enzymes. David Grossman, Popular Mechanics, 2 Aug. 2019

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'macromolecule.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


borrowed from German Makromolekel (later Makromolekül), from makro- macro- + Molekel, Molekül molecule

First Known Use

1924, in the meaning defined above

Time Traveler
The first known use of macromolecule was in 1924

Dictionary Entries Near macromolecule

Cite this Entry

“Macromolecule.” Dictionary, Merriam-Webster, Accessed 25 Jul. 2024.

Medical Definition


mac·​ro·​mol·​e·​cule ˌmak-rō-ˈmäl-i-ˌkyü(ə)l How to pronounce macromolecule (audio)
: a very large molecule (as of a protein, nucleic acid, or rubber) built up from smaller chemical structures compare micromolecule
macromolecular adjective

More from Merriam-Webster on macromolecule

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