irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the state of being irritated

b

: something that irritates

c

: the act of irritating

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part

Synonyms of irritation

• frustration
• exasperation
• annoyance
• displeasure
• grief

Examples of irritation in a Sentence

Dad's general irritation at the incessant complaining coming from the back seat of the car.

Recent Examples on the Web

A little goes a long way, and some folks have complained that this formula can cause irritation or dryness. —Daley Quinn, Glamour, 23 Dec. 2025

Many users report fewer headaches, less irritation in their eyes or throat, and overall greater comfort. —Sarah Jividen, Verywell Health, 23 Dec. 2025

Use vitamin C in the morning and retinol at night to avoid skin irritation. —Sarah Bradley, Health, 23 Dec. 2025

Over time, that irritation erodes the lining, drives inflammation and can change the cells. —Melissa Rudy, FOXNews.com, 22 Dec. 2025

Word History

First Known Use

15th century, in the meaning defined at sense 1c

Rhymes for irritation

• abdication
• aberration
• abjuration
• abnegation
• abrogation
• acceptation
• acclamation
• acclimation
• accusation
• activation
• actuation
• acylation

Kids Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

: the act of irritating : the state of being irritated

2

: irritant entry 2

Medical Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the act of irritating

b

: something that irritates

c

: the state of being irritated

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part