irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the state of being irritated

b

: something that irritates

c

: the act of irritating

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part

Synonyms

• frustration
• exasperation
• annoyance
• displeasure
• grief

Examples of irritation in a Sentence

Dad's general irritation at the incessant complaining coming from the back seat of the car.

Recent Examples on the Web

While prolonged exposure to Castile soap (think jobs that require your hands to be submerged in Castile soap formulas for an extended period of time) can cause skin irritation and dryness, the gentle, fragrance-free formula typically doesn’t cause irritation when used properly. —Patricia Shannon, Southern Living, 2 Oct. 2025

Betaine and glycerin work to support the skin barrier, while antioxidants soothe any existing irritation. —Grace McCarty, Glamour, 1 Oct. 2025

Rubbing Your Eyes Rubbing your eyes might provide immediate relief for itchiness or irritation, but this habit can cause lasting damage. —Stephanie Brown, Verywell Health, 30 Sep. 2025

Acute exposure may cause drowsiness, dizziness and headaches, as well as eye, skin and respiratory tract irritation, and unconsciousness at high levels. —Noelle Phillips, Denver Post, 30 Sep. 2025

Word History

First Known Use

15th century, in the meaning defined at sense 1c

Rhymes for irritation

• abdication
• aberration
• abjuration
• abnegation
• abrogation
• acceptation
• acclamation
• acclimation
• accusation
• activation
• actuation
• acylation

Kids Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

: the act of irritating : the state of being irritated

2

: irritant entry 2

Medical Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the act of irritating

b

: something that irritates

c

: the state of being irritated

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part