irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the state of being irritated

b

: something that irritates

c

: the act of irritating

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part

Synonyms of irritation

• frustration
• exasperation
• annoyance
• displeasure
• grief

Examples of irritation in a Sentence

Dad's general irritation at the incessant complaining coming from the back seat of the car.

Recent Examples on the Web

While many of the more contentious and controversial aspects of his life are presented in one-sided fashion, friend and former manager Rory Holloway’s still-raw sense of betrayal at Tyson firing his entire team is evoked with vivid irritation. — Daniel Fienberg, HollywoodReporter, 13 Oct. 2026

Musk isn’t the sort of guy who’s lets a minor linguistic or chronological irritation get in the way of a grand plan. — Jason Barlow, Robb Report, 11 Oct. 2026

Removing a particularly dry lens could potentially disturb the epithelium, the outer layer of the cornea, causing significant irritation and potentially affecting vision. — Kelly McGreal, FOXNews.com, 11 Oct. 2026

Garrett underwent surgery last month after experiencing irritation in his left knee throughout training camp and during the Rams’ season opener. — Gary Klein, Los Angeles Times, 10 Oct. 2026

Word History

First Known Use

15th century, in the meaning defined at sense 1c

Rhymes for irritation

• abdication
• aberration
• abjuration
• abnegation
• abrogation
• acceptation
• acclamation
• acclimation
• accusation
• activation
• actuation
• acylation

Kids Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

: the act of irritating : the state of being irritated

2

: irritant entry 2

Medical Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the act of irritating

b

: something that irritates

c

: the state of being irritated

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part