irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the state of being irritated

b

: something that irritates

c

: the act of irritating

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part

Synonyms of irritation

• frustration
• exasperation
• annoyance
• displeasure
• grief

Examples of irritation in a Sentence

Dad's general irritation at the incessant complaining coming from the back seat of the car.

Recent Examples on the Web

The emotional discomfort is a result of feeling self-conscious about the appearance, and the physical is typically the result of excess tissue that's more susceptible to everyday irritation. — Anonymous, Allure, 23 July 2026

Artificial tears instantly replenish moisture and soothe irritation. — Helen Carefoot, Flow Space, 22 July 2026

Sweat mixed with bacteria can clog pores and increase breakouts or irritation, especially on the back or chest. — Sherri Gordon, Health, 22 July 2026

Exposure to cyanotoxin through the skin, ingestion, or breathing in water droplets may cause skin irritation, wheezing or coughing, shortness of breath, stomach pain, vomiting, dizziness, or a headache. — Hannah Smith july 21, Idaho Statesman, 21 July 2026

Word History

First Known Use

15th century, in the meaning defined at sense 1c

Rhymes for irritation

• abdication
• aberration
• abjuration
• abnegation
• abrogation
• acceptation
• acclamation
• acclimation
• accusation
• activation
• actuation
• acylation

Kids Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

: the act of irritating : the state of being irritated

2

: irritant entry 2

Medical Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the act of irritating

b

: something that irritates

c

: the state of being irritated

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part