irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the state of being irritated

b

: something that irritates

c

: the act of irritating

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part

Synonyms of irritation

• frustration
• exasperation
• annoyance
• displeasure
• grief

Examples of irritation in a Sentence

Dad's general irritation at the incessant complaining coming from the back seat of the car.

Recent Examples on the Web

The team said imaging was consistent with irritation in the joint of the first toe on his right foot, adding that further updates will be provided as appropriate without providing a timeline for Westbrook’s return. —Jason Anderson, Sacbee.com, 26 Mar. 2026

Side effects can include redness, itching, dryness, flaking, or other scalp irritation, but these are uncommon, according to WebMD. —Miami Herald, 26 Mar. 2026

The formula relies on colloidal oatmeal, an ingredient known for its soothing properties, to calm irritation while helping the skin retain moisture. —Hana Hong, Glamour, 25 Mar. 2026

Since this is a topical product, side effects ‌involve scalp redness, itching, dryness and other signs of irritation. —Rebecca Strong, USA Today, 25 Mar. 2026

Word History

First Known Use

15th century, in the meaning defined at sense 1c

Rhymes for irritation

• abdication
• aberration
• abjuration
• abnegation
• abrogation
• acceptation
• acclamation
• acclimation
• accusation
• activation
• actuation
• acylation

Kids Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

: the act of irritating : the state of being irritated

2

: irritant entry 2

Medical Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the act of irritating

b

: something that irritates

c

: the state of being irritated

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part