irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the state of being irritated

b

: something that irritates

c

: the act of irritating

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part

Synonyms

• frustration
• exasperation
• annoyance
• displeasure
• grief

Examples of irritation in a Sentence

Dad's general irritation at the incessant complaining coming from the back seat of the car.

Recent Examples on the Web

Formula-wise, stabilized retinal is super gentle and minimizes irritation, while ginseng brightens and boosts circulation, and glycerin supports the skin barrier. —Lily Wohlner, Allure, 9 Oct. 2025

Becky Cameron 7-Piece Bedding Bundle This bedding bundle is great for people with allergies, thanks to its down-alternative fill that provides warmth without irritation. —Jacqueline Tempera, PEOPLE, 8 Oct. 2025

For the sensitive skin gals, this cleansing oil will soothe irritation and redness to calm signs of distress. —Conçetta Ciarlo, Vogue, 8 Oct. 2025

Overall emissions are low from geothermal systems, though the systems can release hydrogen sulfide, a corrosive gas that is toxic to humans and can contribute to respiratory irritation. —Moones Alamooti, The Conversation, 8 Oct. 2025

Word History

First Known Use

15th century, in the meaning defined at sense 1c

Rhymes for irritation

• abdication
• aberration
• abjuration
• abnegation
• abrogation
• acceptation
• acclamation
• acclimation
• accusation
• activation
• actuation
• acylation

Kids Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

: the act of irritating : the state of being irritated

2

: irritant entry 2

Medical Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the act of irritating

b

: something that irritates

c

: the state of being irritated

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part