irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the state of being irritated

b

: something that irritates

c

: the act of irritating

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part

Synonyms of irritation

• frustration
• exasperation
• annoyance
• displeasure
• grief

Examples of irritation in a Sentence

Dad's general irritation at the incessant complaining coming from the back seat of the car.

Recent Examples on the Web

Soaking the hair in apple cider vinegar is a common at-home remedy that may help reduce irritation with mixed results. —Leah Asmelash, CNN Money, 28 Feb. 2026

The two-step system is designed to exfoliate and nourish without irritation, so even sensitive skin types can get in on the glow. —Annie Blackman, Allure, 28 Feb. 2026

Most importantly, the ingredients are formulated to prevent irritation, so even those with sensitive skin can add it to their routine. —Caley Sturgill, Southern Living, 27 Feb. 2026

Retinaldehyde requires one conversion step, has moderate strength and delivers faster results than retinol with moderate irritation risk. —Allison Palmer updated February 25, Miami Herald, 25 Feb. 2026

Word History

First Known Use

15th century, in the meaning defined at sense 1c

Rhymes for irritation

• abdication
• aberration
• abjuration
• abnegation
• abrogation
• acceptation
• acclamation
• acclimation
• accusation
• activation
• actuation
• acylation

Kids Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

: the act of irritating : the state of being irritated

2

: irritant entry 2

Medical Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the act of irritating

b

: something that irritates

c

: the state of being irritated

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part