irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the state of being irritated

b

: something that irritates

c

: the act of irritating

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part

Synonyms of irritation

• frustration
• exasperation
• annoyance
• displeasure
• grief

Examples of irritation in a Sentence

Dad's general irritation at the incessant complaining coming from the back seat of the car.

Recent Examples on the Web

According to Smith, people with normal and oily skin can often use standard formulas, whereas those with dry or mature skin should opt for hydrating ones to prevent irritation and creasing. —Caroline Shannon Karasik, InStyle, 15 Mar. 2026

Uncompromising Hygiene and Safety Pregnant and postpartum bodies are often highly sensitive to touch and smell, so much so that, at times, otherwise minor irritations and sensations can feel overwhelming. —Ethan Stone, USA Today, 15 Mar. 2026

Short-term exposure by inhalation can cause headaches, dizziness, nausea, fatigue respiratory irritation and other adverse health effects, according to the federal Agency for Toxic Substances and Disease Registry. —Los Angeles Times, 13 Mar. 2026

This can reduce stomach irritation for some people. —Sara Hoffman, Verywell Health, 12 Mar. 2026

Word History

First Known Use

15th century, in the meaning defined at sense 1c

Rhymes for irritation

• abdication
• aberration
• abjuration
• abnegation
• abrogation
• acceptation
• acclamation
• acclimation
• accusation
• activation
• actuation
• acylation

Kids Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

: the act of irritating : the state of being irritated

2

: irritant entry 2

Medical Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the act of irritating

b

: something that irritates

c

: the state of being irritated

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part