irritability

noun

ir·​ri·​ta·​bil·​i·​ty ˌir-ə-tə-ˈbi-lə-tē 

plural irritabilities

1

: the quality or state of being irritable: such as

a

: quick excitability to annoyance, impatience, or anger : petulance

b

: abnormal or excessive excitability of an organ or part of the body

2

: the property of protoplasm and of living organisms that permits them to react to stimuli

Synonyms of irritability

• irritableness
• aggression
• aggressiveness
• anger
• crankiness
• sensitivity
• peevishness
• grouchiness
• crossness
• petulance
• hostility
• irascibility
• indignation
• grumpiness
• testiness

Examples of irritability in a Sentence

the librarian's well-known irritability makes students hesitant to ask questions

Recent Examples on the Web

Capsaicin, the natural chemical compound in chili peppers, can cause severe irritability in a feline's gastrointestinal system. — Pat Mueller, USA Today, 28 July 2026

Fatigue, low motivation, weight gain and irritability are being reclaimed by primary care as signals of sleep debt, metabolic disease and untreated depression rather than default hormone problems. — Samantha Agate, Kansas City Star, 27 July 2026

Psychological symptoms like anxiety, irritability and depression often show up before physical ones, peaking between ages 41 and 45. — Hanna Wickes, Fort Worth Star-Telegram, 25 July 2026

Flying on an empty stomach is also a bad idea, experts say, because low blood sugar can contribute to fatigue, irritability and dizziness during travel. — Teresa Mull, FOXNews.com, 25 July 2026

Word History

First Known Use

1755, in the meaning defined at sense 2

Rhymes for irritability

• acceptability
• accessibility
• adaptability
• admissibility
• advisability
• affordability
• allowability
• amenability
• amiability
• appealability
• applicability
• availability

Kids Definition

irritability

noun

ir·​ri·​ta·​bil·​i·​ty ˌir-ət-ə-ˈbil-ət-ē 

plural irritabilities

1

: the quality or state of being irritable

especially : readiness to become annoyed or angry

2

: the property of living tissue and living things that permits them to react to stimuli

Medical Definition

irritability

noun

ir·​ri·​ta·​bil·​i·​ty ˌir-ət-ə-ˈbil-ət-ē 

plural irritabilities

1

: the property of protoplasm and of living organisms that permits them to react to stimuli

2

a

: quick excitability to annoyance, impatience, or anger

b

: abnormal or excessive excitability of an organ or part of the body (as the stomach or bladder)