in·​ter·​sti·​tial | \ ˌin-tər-ˈsti-shəl How to pronounce interstitial (audio) \

Definition of interstitial

1 : occurring in or being an interval or intervening space or segment : of, relating to, or forming an interstice an interstitial space … the site has been running interstitial ads, which consist of a full page of advertising between editorial pages, for a little more than a year.— Carl Sullivan
2a : situated within but not restricted to or characteristic of a particular organ or tissue used especially of fibrous tissue
b : affecting the interstitial tissues of an organ or part interstitial cystitis
3 : being or relating to a crystalline compound in which usually small atoms or ions of a nonmetal occupy holes between the larger metal atoms or ions in the crystal lattice

Keep scrolling for more

Other Words from interstitial

interstitially \ ˌin-​tər-​ˈsti-​shə-​lē How to pronounce interstitially (audio) \ adverb

Examples of interstitial in a Sentence

Recent Examples on the Web

Martin also admitted that DOOM 2016's interstitial movement between combat zones was a huge weak point. Sam Machkovech, Ars Technica, "DOOM Eternal gameplay world premiere: Devil horns in the air—literally," 9 June 2019 Belle suffers from interstitial lung disease. and needs a lung transplant. Lucy Wood, Marie Claire, "Meghan Markle and Prince Harry Gave the Coolest Wedding Gift to Idris Elba and Sabrina Dhowre," 29 Apr. 2019 Mae Vogel-Koslow, 2, was diagnosed with pediatric interstitial lung disease four weeks after she was born in February 2016. Fox News, "Toddler walks outside for first time ever after life-saving double lung transplant," 16 July 2018 Bodily fluids including urine, sweat, saliva, ocular fluids like tears, and interstitial fluids, which bathe cells, also contain glucose and are easier to get to than blood. Deborah Gage, WSJ, "Wearable Health Monitors: Do They Work?," 16 Sep. 2018 In strange interstitial chapters, Kushner also includes short excerpts from the diary of Ted Kaczynski, the Unabomber, which Gordon is reading. Josephine Livingstone, The New Republic, "The bold, vivid worlds of Rachel Kushner’s novels," 7 June 2018 These interstitial monologues were fascinatingly bizarre, full of aimless asides and mildly humorous observations at which the worshipful crowd always laughed slightly louder than was warranted. Terence Cawley,, "At the Wang, a free-wheeling journey through Neil Young’s past," 12 July 2018 If accessing true accu-points allows interstitial fluids to travel throughout the body, that might account for the difference. Katie Heaney, The Cut, "Do We Finally Understand How Acupuncture Works?," 30 Mar. 2018 The best parts of the film come in interstitial shots that establish atmosphere. Josephine Livingstone, The New Republic, "Poor Mary Shelley!," 23 May 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'interstitial.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

See More

First Known Use of interstitial

1646, in the meaning defined at sense 1

Keep scrolling for more

Learn More about interstitial

Statistics for interstitial

Last Updated

25 Jun 2019

Look-up Popularity

Time Traveler for interstitial

The first known use of interstitial was in 1646

See more words from the same year

Keep scrolling for more

More Definitions for interstitial


in·​ter·​sti·​tial | \ ˌint-ər-ˈstish-əl How to pronounce interstitial (audio) \

Medical Definition of interstitial

1 : situated within but not restricted to or characteristic of a particular organ or tissue used especially of fibrous tissue
2 : affecting the interstitial tissues of an organ or part interstitial hepatitis
3 : occurring in the part of a fallopian tube in the wall of the uterus interstitial pregnancy

Other Words from interstitial

interstitially \ -​ə-​lē How to pronounce interstitially (audio) \ adverb

More from Merriam-Webster on interstitial

Rhyming Dictionary: Words that rhyme with interstitial

Britannica English: Translation of interstitial for Arabic Speakers

Comments on interstitial

What made you want to look up interstitial? Please tell us where you read or heard it (including the quote, if possible).


having no luck

Get Word of the Day daily email!

Test Your Vocabulary

What's that Smell?! Quiz

  • wide eyed dog smelling rose
  • Someone who is hircine smells like a:
Spell It

Can you spell these 10 commonly misspelled words?


Test Your Knowledge - and learn some interesting things along the way.

Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!