interstitial
adjective
in·ter·sti·tial
ˌin-tər-ˈsti-shəl 
1
: occurring in or being an interval or intervening space or segment : of, relating to, or forming an interstice
an interstitial space
… the site has been running interstitial ads, which consist of a full page of advertising between editorial pages, for a little more than a year.—
Carl Sullivan
Carl Sullivan2
a
: situated within but not restricted to or characteristic of a particular organ or tissue
—used especially of fibrous tissue
b
: affecting the interstitial tissues of an organ or part
interstitial cystitis
3
: being or relating to a crystalline compound in which usually small atoms or ions of a nonmetal occupy holes between the larger metal atoms or ions in the crystal lattice
Examples of interstitial in a Sentence
Recent Examples on the Web
Realize or continue to check that there's no such thing as an interstitial moment because either everything is sacred or nothing is sacred.
—Outside Online, 25 June 2025
The researchers observed that patients and mice with breast cancer had high concentrations of aspartate in their interstitial fluid, the fluid that fills the spaces between the air sacs and surrounding blood vessels in the lungs.
—New Atlas, 1 Jan. 2025
This book, as the interstitial pieces remind us, give us new rituals for looking, exposing the casually oppressive structures of our society and imbuing trash with a newfound sense of purpose.
—Literary Hub, 27 June 2025
Kanshi Iwasaki’s sound design, meanwhile, is tensely sparse and defined by absence, giving way to music only in interstitial montages of relentlessly forward-driving city life.
—Guy Lodge, Variety, 13 June 2025
See All Example Sentences for interstitial
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Outside Online, 25 June 2025
The researchers observed that patients and mice with breast cancer had high concentrations of aspartate in their interstitial fluid, the fluid that fills the spaces between the air sacs and surrounding blood vessels in the lungs.
—New Atlas, 1 Jan. 2025
This book, as the interstitial pieces remind us, give us new rituals for looking, exposing the casually oppressive structures of our society and imbuing trash with a newfound sense of purpose.
—Literary Hub, 27 June 2025
Kanshi Iwasaki’s sound design, meanwhile, is tensely sparse and defined by absence, giving way to music only in interstitial montages of relentlessly forward-driving city life.
—Guy Lodge, Variety, 13 June 2025
See All Example Sentences for interstitial
Cite this Entry
“Interstitial.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/interstitial. Accessed 8 Aug. 2025.
Copy CitationKids Definition
interstitial
adjective
in·ter·sti·tial
ˌint-ər-ˈstish-əl
: relating to or located in the interstices
Medical Definition
interstitial
adjective
in·ter·sti·tial
ˌint-ər-ˈstish-əl
1
: situated within but not restricted to or characteristic of a particular organ or tissue
—used especially of fibrous tissue
2
: affecting the interstitial tissues of an organ or part
interstitial hepatitis
3
: occurring in the part of a fallopian tube in the wall of the uterus
interstitial pregnancy
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