hypermutable

adjective

hy·​per·​mu·​ta·​ble ˌhī-pər-ˈmyü-tə-bəl How to pronounce hypermutable (audio)
: exhibiting or capable of excessive mutation or change
Only the hypermutable cells that subsequently achieve a beneficial mutation would survive; the others would cease to be viable.John Rennie
Another severe obstacle for those with compromised immune systems: the hypermutable bacteria that can be found in cystic fibrosis patients. These chameleon-like germs produce numerous mutations when they replicate, creating more potential possibilities for drug resistance.Jim Doyle
hypermutability noun
"What we've found is a subtle alteration in the genetic code that causes DNA instability and leads to hypermutability, or a cascade of mutations in surrounding genes …" Kenneth Kinzler

Word History

First Known Use

1959, in the meaning defined above

Time Traveler
The first known use of hypermutable was in 1959

Dictionary Entries Near hypermutable

Cite this Entry

“Hypermutable.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/hypermutable. Accessed 4 Feb. 2023.

Medical Definition

hypermutable

adjective
hy·​per·​mu·​ta·​ble -ˈmyüt-ə-bəl How to pronounce hypermutable (audio)
: exhibiting or capable of excessive mutation or change
Another severe obstacle for those with compromised immune systems: the hypermutable bacteria that can be found in cystic fibrosis patients. These chameleon-like germs produce numerous mutations when they replicate, creating more potential possibilities for drug resistance.Jim Doyle, The Birmingham (Alabama) News
hypermutability noun
"What we've found," he [Kenneth Kinzler] explained, "is a subtle alteration in the genetic code that causes DNA instability and leads to hypermutability, or a cascade of mutations in surrounding genes." Newsday (Melville, New York)
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