hy·​dro·​chlo·​ride ˌhī-drə-ˈklȯr-ˌīd How to pronounce hydrochloride (audio)
: a chemical complex composed of an organic base (such as an alkaloid) in association with hydrogen chloride

Examples of hydrochloride in a Sentence

Recent Examples on the Web There are several forms of creatine, including creatine ethyl ester, creatine hydrochloride, creatine magnesium chelate, and creatine monohydrate. Tamar Kane, Ms, Verywell Health, 25 Jan. 2024 Although the off-label use of ketamine hydrochloride, a Schedule III drug approved by the FDA as an anesthetic in 1970, was considered radical just a decade ago, now between 500 and 750 ketamine clinics have cropped up across the nation. Dawn Megli | Kff Health News, ABC News, 31 Jan. 2024 Then the barnacles were stained with tetracycline hydrochloride, which fluoresces under UV light, to track where new shell growth occurred. Jennifer Ouellette, Ars Technica, 24 Aug. 2023 This supplement contains glucosamine hydrochloride and chondroitin sulfate, which promote cartilage production and protect existing joint tissue. Amber Smith, Discover Magazine, 30 July 2023 Hinkle also modified the recipe to incorporate vitamin B1 in the form of thiamine hydrochloride—useful in tropical climates, where troops might be susceptible to vitamin deficiencies and associated diseases, like beriberi. Kovie Biakolo, Smithsonian Magazine, 25 Oct. 2023 To demonstrate the machine’s range, the MIT team produced four pharmaceuticals: diphenhydramine hydrochloride (Benadryl), diazepam (Valium), fluoxetine hydrochloride (Prozac), and the local anesthetic lidocaine hydrochloride. IEEE Spectrum, 31 Mar. 2016 These soft chews, which are stuffed with glucosamine hydrochloride and chondroitin sulfate, assist cartilage development and joint cushioning. Amber Smith, Discover Magazine, 1 Aug. 2023 The patch includes fentanyl hydrochloride, a kind of salt that allows the medication in the patch to dissolve through the skin and enter the bloodstream. Kerry Breen, CBS News, 21 Sep. 2023

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'hydrochloride.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1826, in the meaning defined above

Time Traveler
The first known use of hydrochloride was in 1826

Dictionary Entries Near hydrochloride

Cite this Entry

“Hydrochloride.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/hydrochloride. Accessed 22 May. 2024.

Medical Definition


hy·​dro·​chlo·​ride -ˈklō(ə)r-ˌīd, -ˈklȯ(ə)r- How to pronounce hydrochloride (audio)
: a salt of hydrochloric acid with an organic base used especially as a vehicle for the administration of a drug
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