hemoglobin S

noun

: an abnormal hemoglobin that occurs in the red blood cells in sickle cell anemia and sickle-cell trait

Examples of hemoglobin S in a Sentence

Recent Examples on the Web
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However, if one parent passes down the hemoglobin S gene and the other does not, the child will only carry the sickle cell trait. — Maggie Aime, Msn, Health, 20 Sep. 2024 The result is hemoglobin S—a misshapen version that causes red blood cells to sickle. — Dhruv Khullar, The New Yorker, 22 Mar. 2022

Word History

First Known Use

1954, in the meaning defined above

Time Traveler
The first known use of hemoglobin S was in 1954

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Cite this Entry

“Hemoglobin S.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/hemoglobin%20S. Accessed 28 Sep. 2026.

Medical Definition

hemoglobin S

noun
: an abnormal hemoglobin occurring in the red blood cells in sickle cell anemia and sickle-cell trait and differing from hemoglobin A in having a valine residue substituted for the glutamic-acid residue in position 6 of two of the four polypeptide chains making up the hemoglobin molecule

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