gyr·​ase | \ ˈjī-ˌrās How to pronounce gyrase (audio) \

Definition of gyrase

: a bacterial enzyme that catalyzes the breaking and rejoining of bonds linking adjacent nucleotides in circular DNA to generate supercoiled DNA helices

First Known Use of gyrase

1976, in the meaning defined above

History and Etymology for gyrase

gyr- + -ase

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The first known use of gyrase was in 1976

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gy·​rase | \ ˈjī-ˌrās, -ˌrāz How to pronounce gyrase (audio) \

Medical Definition of gyrase

: a bacterial enzyme that is a topoisomerase which catalyzes the ATP-dependent breaking and rejoining of double-strands in circular DNA to generate negative supercoils that twist in the opposite direction as the turns in the original helices

Note: The supercoils introduced by the bacterial gyrase help to relieve the torsional stress in the circular DNA strands that is a consequence of the unwinding of the DNA during replication.

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