glucose-dependent insulinotropic polypeptide

noun

variants or less commonly glucose-dependent insulinotropic peptide

: an intestinal polypeptide hormone that stimulates insulin secretion by the pancreas in response to the presence of glucose in the small intestine especially following meal ingestion : gastric inhibitory polypeptide

Tirzepatide mimics two hormones naturally produced in the body: glucagon-like peptide-1, or GLP-1, and glucose-dependent insulinotropic polypeptide. … Researchers believe tirzepatide may be so effective at lowering blood sugar levels and inducing weight loss because the two hormones it imitates work in a synergistic way.

—The New York Times

—abbreviation GIP

Word History

Etymology

insulin + -o- -tropic

First Known Use

1978, in the meaning defined above

Rhymes for glucose-dependent insulinotropic polypeptide

• abide
• allied
• applied
• aside
• astride
• azide
• backside
• bankside
• bastide
• bayside
• bedside
• belied

Medical Definition

glucose-dependent insulinotropic polypeptide

noun

variants also glucose-dependent insulinotropic peptide

: gastric inhibitory polypeptide

The incretins (i.e., glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide) are intestinal hormones that stimulate the postprandial production of insulin and glucagon by the pancreas.

—Amy G. Egan et al., The New England Journal of Medicine

—abbreviation GIP