genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

Read More: The Surprising Reason Rural Hospitals Are Closing CRISPR, with its ability to target specific genetic mutations, holds the most promise for changing the course of such diseases. —Alice Park, Time, 8 July 2025

In Zoë's case, a genetic mutation in the gene TFE3 makes her cancer even rarer and more difficult to treat, according to the GoFundMe. —Michael Nied, People.com, 7 July 2025

The study, led by researchers from Stanford University, California, involved a form of the neurodegenerative disorder that is caused by a single genetic mutation. —Ian Randall, MSNBC Newsweek, 1 July 2025

Nine hundred years ago, before the advent of intentional cat breeding, a genetic mutation gave rise to the first orange cat. —Jia H. Jung, Mercury News, 28 May 2025

Word History

First Known Use

1915, in the meaning defined above

Rhymes for genetic mutation

• acclimatisation
• acclimatization
• acidification
• actualization
• annualization
• autocorrelation
• autoregulation
• beatification
• beneficiation
• biodegradation
• biotransformation
• bureaucratization

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper