genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

The split-coloring is believed to be caused by either a genetic mutation or pigment irregularities, according to scientists. —Melina Khan, USA Today, 23 Apr. 2026

When conventional treatments failed, doctors looked for a bone marrow donor, specifically, for one with a genetic mutation (CCR5 delta 32) that has been shown in studies to inhibit HIV infections. —Cara Lynn Shultz, PEOPLE, 15 Apr. 2026

When a person has two copies of this genetic mutation, the CCR5 surface protein, to which HIV commonly binds, is prevented from being expressed on human immune cells called T cells. —Emma Gometz, Scientific American, 13 Apr. 2026

Mastectomies intended to prevent breast cancer have become more common among women with elevated risks, including genetic mutations and a family history of the disease. —CNN Money, 11 Apr. 2026

Word History

First Known Use

1915, in the meaning defined above

Rhymes for genetic mutation

• acclimatisation
• acclimatization
• acidification
• actualization
• annualization
• autocorrelation
• autoregulation
• beatification
• beneficiation
• biodegradation
• biotransformation
• bureaucratization

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper