exonuclease

noun

exo·​nu·​cle·​ase ˌek-sō-ˈnü-klē-ˌās How to pronounce exonuclease (audio)
-ˈnyü-
-ˌāz
: an enzyme that breaks down a nucleic acid by removing nucleotides one by one from the end of a chain compare endonuclease

Examples of exonuclease in a Sentence

Recent Examples on the Web
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One of these advantageous proteins is an enzyme called exonuclease (ExoN), which helps the virus proofread and correct copies as they are made. Mark Fischetti, Scientific American, 23 June 2020

Word History

First Known Use

1963, in the meaning defined above

Time Traveler
The first known use of exonuclease was in 1963

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Cite this Entry

“Exonuclease.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/exonuclease. Accessed 30 Jul. 2026.

Medical Definition

: an enzyme that breaks down a nucleic acid by removing nucleotides one by one from the end of a chain compare endonuclease
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