Definition of endonuclease
: an enzyme that breaks down a nucleotide chain into two or more shorter chains by cleaving the internal covalent bonds linking nucleotides — compare exonuclease
First Known Use of endonuclease
Learn More about endonuclease
Britannica.com: Encyclopedia article about endonuclease
Seen and Heard
What made you want to look up endonuclease? Please tell us where you read or heard it (including the quote, if possible).