estradiol

noun

es·​tra·​di·​ol ˌe-strə-ˈdī-ˌȯl  -ˌōl 

: a natural estrogenic hormone that is a phenolic alcohol C₁₈H₂₄O₂ secreted chiefly by the ovaries, that is the most potent of the naturally occurring estrogens, and that is administered in its natural or semisynthetic esterified form especially to treat menopausal symptoms

Examples of estradiol in a Sentence

Recent Examples on the Web

Some women may also consider a vaginal estradiol ring called Femring, says Cole. —Tom Gavin, EverydayHealth.com, 26 Feb. 2026

The estradiol patch, a tiny square worn on the skin, may be discreet, but its impact is powerful. —Jacqueline Howard, CNN Money, 23 Feb. 2026

Sales of estradiol patches are up more than 200% from five years ago. —Emma Hinchliffe, Fortune, 9 Feb. 2026

According to the American College of Obstetricians and Gynecologists, estrogen hormone therapy — which includes estradiol patches — is the most effective treatment for hot flashes and night sweats. —Marina Kopf, NBC news, 3 Feb. 2026

Word History

Etymology

International Scientific Vocabulary estra- (from estrane parent compound of estradiol, from New Latin estrus + English -ane) + di- + -ol entry 1

First Known Use

1934, in the meaning defined above

Phrases Containing estradiol

• ethinyl estradiol

Rhymes for estradiol

• oestradiol
• interradial
• radial

Medical Definition

estradiol

noun

es·​tra·​di·​ol ˌes-trə-ˈdī-ˌȯl  -ˌōl 

variants or chiefly British oestradiol

ˌē-strə-ˈdī-ˌȯl  ē-ˈstrad-ē-ˌȯl 

-ˌōl

: a natural estrogenic hormone that is a phenolic alcohol C₁₈H₂₄O₂ secreted chiefly by the ovaries, is the most potent of the naturally occurring estrogens, and is administered in its natural or semisynthetic esterified form especially to treat menopausal symptoms

called also dihydrotheelin

see estrace, estraderm, estring