epi·​ge·​nome | \ ˌe-pə-ˈjē-ˌnōm How to pronounce epigenome (audio) \

Definition of epigenome

: the complement of chemical compounds that modify the expression and function of the genome Access to the genes is controlled by the epigenome, a layer of millions of proteins and other marks that attach themselves to the genome.— Nicholas Wade Working out which genes are switched on or not involves looking at the epigenome, or the chemical "methyl" tags attached to genes.New Scientist

Examples of epigenome in a Sentence

Recent Examples on the Web David had long suspected that the epigenome was central to longevity. Margaret Talbot, The New Yorker, 11 Aug. 2021 David published a great paper in Nature late last year showing that in mice Yamanaka gene therapy can safety reprogram the epigenome of the retina and restore vision in a mouse model of glaucoma. Alex Zhavoronkov, Forbes, 14 June 2021 Penick said the Indian jumping ant colonies used in the study were the same ones that were collected in India almost 20 years ago and were the first epigenome for the species sequenced. NBC News, 14 Apr. 2021 Molecular biologist David Sinclair of Harvard Medical School, who has long been on the hunt for antiaging strategies, has also looked for signs of aging in the epigenome. Kelly Servick, Science | AAAS, 2 Dec. 2020 The Stanford approach utilizes powerful agents known as Yamanaka factors, which reprogram a cell’s epigenome to its time zero, or embryonic state. Nicholas Wade, New York Times, 24 Mar. 2020 Skinner's own research in animals suggests changes to the epigenome, a swirl of biological factors that affect how genes are expressed, can be passed down through multiple generations. Andrew Curry, Science | AAAS, 18 July 2019 One intriguing finding in the twin study was that changes the researchers noted in Kelly’s genome and epigenome (markers on our genes that develop in response to environmental stressors) occurred in the last six months of the mission. Brian Resnick, Vox, 18 July 2019 Environmental factors such as diet, stress, and sun exposure can affect the epigenome. Marcia Desanctis, Vogue, 21 July 2018

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'epigenome.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of epigenome

1991, in the meaning defined above

History and Etymology for epigenome

epi- + genome, after epigenetic

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The first known use of epigenome was in 1991

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Last Updated

18 Aug 2021

Cite this Entry

“Epigenome.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/epigenome. Accessed 24 Sep. 2021.

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