differentiate

verb

dif·​fer·​en·​ti·​ate ˌdi-fə-ˈren(t)-shē-ˌāt 

differentiated; differentiating

transitive verb

1

mathematics : to obtain the mathematical derivative (see derivative entry 1 sense 3) of

2

: to mark or show a difference in : constitute a contrasting element that distinguishes

features that differentiate the twins

how we differentiate ourselves from our competitors

3

: to develop differential or distinguishing characteristics in

What differentiated a laborer from another man …

—Sherwood Anderson

4

biology : to cause differentiation (see differentiation sense 3b) of in the course of development

cells that are differentiated from stem cells

5

: to express the specific distinguishing quality of : discriminate

differentiate poetry and prose

intransitive verb

1

: to recognize or give expression to a difference

difficult to differentiate between the two

2

: to become distinct or different in character

3

biology : to undergo differentiation (see differentiation sense 3b)

when the cells begin to differentiate

differentiability

ˌdi-fə-ˌren(t)-sh(ē-)ə-ˈbi-lə-tē 

noun

differentiable

ˌdi-fə-ˈren(t)-sh(ē-)ə-bəl 

adjective

Synonyms

• difference
• discern
• discriminate
• distinguish
• secern
• separate

Examples of differentiate in a Sentence

The only thing that differentiates the twins is the color of their eyes.

it was hard at first to differentiate between the two styles of music

Recent Examples on the Web

This structure differentiates Microsoft Teams from other messaging apps. —PC Magazine, 17 June 2025

The model could identify risk two days earlier than other models that had attempted to predict bad outcomes; CONCERN differentiated itself by tapping into nurses' practices and detecting patterns of concern in their documentation. —Alexis Kayser, MSNBC Newsweek, 12 June 2025

When fish suffer retinal damage, the Müller glia cells differentiate into retinal progenitor cells, which generate new neurons and help the fish keep their vision functioning properly. —Michael Franco, New Atlas, 11 June 2025

However, given that many in law enforcement personnel dress in military-like uniforms, the public may not differentiate between troops and law enforcement. —Tom Vanden Brook, USA Today, 11 June 2025

Word History

Etymology

probably borrowed from Medieval Latin differentiātus, past participle of differentiāre "to distinguish" (New Latin in mathematical sense), verbal derivative of Latin differentia difference entry 1

First Known Use

1814, in the meaning defined at transitive sense 1

Rhymes for differentiate

• borosilicate
• decontaminate
• deoxycholate
• deteriorate
• diisocyanate
• dinoflagellate
• excommunicate
• incapacitate
• insubordinate
• intercorporate
• interpenetrate
• isocyanate

Kids Definition

differentiate

verb

dif·​fer·​en·​ti·​ate ˌdif-ə-ˈren-chē-ˌāt 

differentiated; differentiating

1

: to make or become different in some way

the color of their eyes differentiates the twins

2

: to undergo or cause to undergo differentiation in the course of development

3

: to see or state the difference or differences

differentiate between two plants

Medical Definition

differentiate

verb

dif·​fer·​en·​ti·​ate ˌdif-ə-ˈren-chē-ˌāt 

differentiated; differentiating

transitive verb

1

: to constitute a difference that distinguishes

the history of the injury also differentiates these two fractures

—J. S. Keene et al.

2

: to cause differentiation of in the course of development

3

: to discriminate or give expression to a specific difference that distinguishes

quickly learned to differentiate sharp pain from dull pain

4

: to cause differentiation in (a specimen for microscopic examination) by staining

intransitive verb

1

: to recognize or express a difference

differentiate between humans and the rest of the primates

2

: to undergo differentiation

when a B cell matures, it differentiates into a plasma cell that secretes antibodies

—R. C. Gallo