de novo

adverb or adjective
de no·​vo | \ di-ˈnō-(ˌ)vō How to pronounce de novo (audio) , dā-, dē- \

Definition of de novo

: over again : anew a case tried de novo

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Synonyms & Antonyms for de novo

Synonyms

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Examples of de novo in a Sentence

Recent Examples on the Web Akili is seeking authorization to market its game under the de novo pathway — meant for relatively safe medical devices and software without precedent. Rebecca Robbins, STAT, "Awaiting an FDA decision, Akili rolls out its video game for kids with ADHD under relaxed rules," 22 Apr. 2020 Yet, in a strict sense, nothing in evolution is created de novo. Quanta Magazine, "Where Do New Genes Come From?," 9 Apr. 2020 That confirmed that the de novo mutations were indeed playing some role in contributing to autism. Alice Park, Time, "Genetic Mutations In Father’s Sperm Can Predict Children’s Autism Risk," 23 Dec. 2019 In the time since, it was hotly debated, and Holland’s new research helps to settle some parts of that debate while hopefully igniting further interest in researching how and why body cells undergo de novo generation of cilia. Caroline Delbert, Popular Mechanics, "Mammalian Cells Are More Mysterious Than We Thought," 30 Dec. 2019 Akili is seeking authorization to market its game under the de novo pathway — meant for relatively safe medical devices and software without precedent. Rebecca Robbins, STAT, "Will the FDA give the go-ahead to a prescription video game? The wait goes on, as new data come in," 21 Jan. 2020 In fact, cells that generate their own cilia without centrioles or deuterosomes already have a name: de novo, basically meaning spontaneous generation. Caroline Delbert, Popular Mechanics, "Mammalian Cells Are More Mysterious Than We Thought," 30 Dec. 2019 Not only do mammalian cells have potential to exhibit de novo generation of cilia—someone predicted this in 1968. Caroline Delbert, Popular Mechanics, "Mammalian Cells Are More Mysterious Than We Thought," 30 Dec. 2019 The next step is to better understand how de novo mutations function over time. Alice Park, Time, "Genetic Mutations In Father’s Sperm Can Predict Children’s Autism Risk," 23 Dec. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'de novo.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of de novo

1536, in the meaning defined above

History and Etymology for de novo

Latin

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The first known use of de novo was in 1536

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Cite this Entry

“De novo.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/de%20novo. Accessed 11 Aug. 2020.

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More Definitions for de novo

de novo

adverb or adjective
de no·​vo | \ dē-ˈnō-vō, dā- How to pronounce de novo (audio) \

Legal Definition of de novo

: over again : as if for the first time: as
a : allowing independent appellate determination of issues (as of fact or law) a de novo review
b : allowing complete retrial upon new evidence — compare abuse of discretion, clearly erroneous

Note: A de novo review is an in-depth review. Decisions of federal administrative agencies are generally subject to de novo review in the U.S. District Courts, and some lower state court decisions are subject to de novo review at the next level.

History and Etymology for de novo

Medieval Latin, literally, from (the) new

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