cyclosporine

noun

cy·​clo·​spor·​ine ˌsī-klə-ˈspȯr-ən How to pronounce cyclosporine (audio)
-ˌēn
variants or less commonly cyclosporin
: an immunosuppressive drug C62H111N11O12 that is a cyclic polypeptide obtained as a metabolite from a fungus (Tolypocladium inflatum synonym Beauveria nivea) and is used especially to prevent rejection of transplanted organs and in the treatment of rheumatoid arthritis and psoriasis

Examples of cyclosporine in a Sentence

Recent Examples on the Web Immunosuppressants like cyclosporine, prednisone, and Rituxan (rituximab) can help control some primary causes of nephrotic syndrome. Kashif J. Piracha, Verywell Health, 12 July 2024 Bio-ethicist and psychiatrist Dr. Jacob Appel helps Lane understand the history of progress in kidney transplantation, which came rapidly after the discovery of cyclosporine, an immunosuppressive agent used to treat organ rejection post-transplant. Alissa Simon, Variety, 26 June 2024 Some immunosuppressants a healthcare provider may prescribe include cyclosporine or hydroxychloroquine. Karen Pallarito, Health, 24 Mar. 2024 By the mid-1970s, Dr. Calne was testing a new immunosuppressive drug, cyclosporine, championed by Jean-François Borel of the Swiss pharmaceutical company Sandoz. Harrison Smith, Washington Post, 17 Jan. 2024 See all Example Sentences for cyclosporine 

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'cyclosporine.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

Etymology

International Scientific Vocabulary cycl- + spor- + -ine entry 2

First Known Use

1976, in the meaning defined above

Time Traveler
The first known use of cyclosporine was in 1976

Dictionary Entries Near cyclosporine

Cite this Entry

“Cyclosporine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cyclosporine. Accessed 13 Oct. 2024.

Medical Definition

cyclosporine

noun
cy·​clo·​spor·​ine ˌsī-klə-ˈspȯr-ᵊn, -ˌēn How to pronounce cyclosporine (audio)
variants also cyclosporin
ˌsī-klə-ˈspȯr-ᵊn
or cyclosporine A or cyclosporin A or chiefly British ciclosporin or ciclosporin A
: a cyclosporin C62H111N11O12 that is an immunosuppressive cyclic polypeptide obtained as a metabolite from a fungus (Beauveria nivea synonym Tolypocladium inflatum) and is used especially to prevent rejection of transplanted organs and in the treatment of rheumatoid arthritis and psoriasis
The indications for treatment with cyclosporine are rapidly expanding. Once used only for the prevention of organ transplant rejection, cyclosporine is now approved for psoriasis and rheumatoid arthritis and is being prescribed for conditions ranging from autoimmune diseases to atopic dermatitis.Mark Lebwohl, Scientitic American Medicine Bulletin
Recently, cyclosporine has come on the market as an especially useful immunosuppressive agent, since it offers essentially equal protection from rejection of the transplant, while causing less impairment of immunological defenses against bacteria and viruses.James D. Hardy, The World of Surgery
Cyclosporin, an antirejection drug that helps make organ transplants feasible, comes from a Norwegian fungus.Jon R. Luoma, Audubon
Prolonged treatment with glucocorticoids can have undesirable side effects (including diabetes mellitus), while cyclosporine A can cause diarrhea and vomiting (and diminished bank accounts for owners of large dogs).Dog Watch

Note: Trademarks for cyclosporine include Neoral, Restasis, and Sandimmune.

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