poly·​pep·​tide ˌpä-lē-ˈpep-ˌtīd How to pronounce polypeptide (audio)
: a molecular chain of amino acids
polypeptidic adjective

Examples of polypeptide in a Sentence

Recent Examples on the Web Glow Recipe Pomegranate Firming Serum With antioxidant-rich pomegranate and collagen-boosting polypeptides (a blend of signal peptides and copper tri-peptides) working together, the Pomegranate Peptide Firming Serum targets fine lines and wrinkles with its lifting and tightening formula. Emily Belfiore, Travel + Leisure, 17 Sep. 2023 While semaglutide targets one molecule, glucagon-like peptide-1 (GLP-1), involved in insulin secretion, tirzepatide is the first to target two: GLP-1 and glucose-dependent insulinotropic polypeptide (GIP). Alice Park, Time, 6 June 2023 What’s missing from such previous complexity measures, Cronin said, is any sense of the history of the complex object — the measures don’t distinguish between an enzyme and a random polypeptide. Philip Ball, Quanta Magazine, 4 May 2023 This supplement powder is rich in immunoglobulin, lactoferrin, and proline-rich polypeptides (PRPs), all of which work together to support immune function and protect against infection. Amber Smith, Discover Magazine, 25 Apr. 2023 Mounjaro, also known as tirzepatide, acts on a combination of two hormones: GLP-1 and GIP (glucose-dependent insulinotropic polypeptide). Mira Miller, Verywell Health, 18 Apr. 2023 Mounjaro is the only dual-acting glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved to improve glycemic control in adults with type 2 diabetes in addition to diet and exercise. Verywell Health, 2 Feb. 2023 Second, tirzepatide has also been shown to bind to receptors that are normally targeted by glucose-dependent insulinotropic polypeptide (GIP) hormones. William A. Haseltine, Forbes, 24 Jan. 2023 Repeats with a lot of proline, threonine and serine transform a typical protein to a mucin because of the polypeptide structure that is formed. Coren Walters-Stewart, Discover Magazine, 18 Oct. 2022 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'polypeptide.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History


International Scientific Vocabulary

First Known Use

1903, in the meaning defined above

Time Traveler
The first known use of polypeptide was in 1903

Dictionary Entries Near polypeptide

Cite this Entry

“Polypeptide.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/polypeptide. Accessed 4 Dec. 2023.

Medical Definition


poly·​pep·​tide ˌpäl-i-ˈpep-ˌtīd How to pronounce polypeptide (audio)
: a molecular chain of amino acids
polypeptidic adjective

More from Merriam-Webster on polypeptide

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