cyclosporine

noun
cy·​clo·​spor·​ine | \ ˌsī-klə-ˈspȯr-ən How to pronounce cyclosporine (audio) , -ˌēn \
variants: or less commonly cyclosporin \ ˌsī-​klə-​ˈspȯr-​ən How to pronounce cyclosporine (audio) \

Definition of cyclosporine

: an immunosuppressive drug C62H111N11O12 that is a cyclic polypeptide obtained as a metabolite from a fungus (Beauveria nivea synonym Tolypocladium inflatum) and is used especially to prevent rejection of transplanted organs and in the treatment of rheumatoid arthritis and psoriasis

Examples of cyclosporine in a Sentence

Recent Examples on the Web One of the tale’s greatest heroes is the drug cyclosporine, approved in 1983 for use in transplants. Star Tribune, "Review: 'When Death Becomes Life,' by Joshua D. Mezrich," 21 Aug. 2020 For more widespread disease, systemic therapy is generally required, which can involve either oral medication (like methotrexate, acitretin, or cyclosporine) or injectable biologic medications (like Enbrel, Humira or Stelara). Lambeth Hochwald, Health.com, "What to Know About Pustular Psoriasis, According to Dermatologists," 29 Aug. 2019 Isolated from a soil fungus found in Africa, cyclosporine was synthesized as an immunosuppressant by the pharmaceutical company Sandoz in 1980, and after wide testing was released into the market in 1983. oregonlive, "The tragic, redemptive journey of one human heart," 5 Oct. 2019 Systemic therapies for psoriasis include oral therapy (such as methotrexate, cyclosporine, oral retinoids, and apremilast) as well as numerous injectable biologic and biosimilar medications. Jenna Birch, SELF, "How to Find the Right Psoriasis Treatment for Your Symptoms," 28 Oct. 2019 Are or may be pregnant, have osteoporosis, have severe liver disease, or take medicines known as strong OATP1B1 inhibitors, such as cyclosporine or gemfibrozil. Vogue, "Danish Jewelry Designer Vibe Harsløf’s Riffs on the Omnipresent EarPod are Something to Shout About," 23 Aug. 2019 Are or may be pregnant, have osteoporosis, have severe liver disease, or take medicines known as strong OATP1B1 inhibitors, such as cyclosporine or gemfibrozil. Vogue, "Danish Jewelry Designer Vibe Harsløf’s Riffs on the Omnipresent EarPod are Something to Shout About," 23 Aug. 2019 Are or may be pregnant, have osteoporosis, have severe liver disease, or take medicines known as strong OATP1B1 inhibitors, such as cyclosporine or gemfibrozil. Vogue, "Danish Jewelry Designer Vibe Harsløf’s Riffs on the Omnipresent EarPod are Something to Shout About," 23 Aug. 2019 Are or may be pregnant, have osteoporosis, have severe liver disease, or take medicines known as strong OATP1B1 inhibitors, such as cyclosporine or gemfibrozil. Vogue, "Danish Jewelry Designer Vibe Harsløf’s Riffs on the Omnipresent EarPod are Something to Shout About," 23 Aug. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'cyclosporine.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of cyclosporine

1976, in the meaning defined above

History and Etymology for cyclosporine

International Scientific Vocabulary cycl- + spor- + -ine entry 2

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Time Traveler for cyclosporine

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The first known use of cyclosporine was in 1976

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Cite this Entry

“Cyclosporine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cyclosporine. Accessed 25 Jan. 2021.

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More Definitions for cyclosporine

cyclosporine

noun
cy·​clo·​spor·​ine | \ ˌsī-klə-ˈspȯr-ᵊn, -ˌēn How to pronounce cyclosporine (audio) \
variants: also cyclosporin \ ˌsī-​klə-​ˈspȯr-​ᵊn \ or cyclosporine A or cyclosporin A or chiefly British ciclosporin or ciclosporin A

Medical Definition of cyclosporine

: a cyclosporin C62H111N11O12 that is an immunosuppressive cyclic polypeptide obtained as a metabolite from a fungus (Beauveria nivea synonym Tolypocladium inflatum) and is used especially to prevent rejection of transplanted organs and in the treatment of rheumatoid arthritis and psoriasis The indications for treatment with cyclosporine are rapidly expanding. Once used only for the prevention of organ transplant rejection, cyclosporine is now approved for psoriasis and rheumatoid arthritis and is being prescribed for conditions ranging from autoimmune diseases to atopic dermatitis.— Mark Lebwohl, Scientitic American Medicine Bulletin, February 2000 Recently, cyclosporine has come on the market as an especially useful immunosuppressive agent, since it offers essentially equal protection from rejection of the transplant, while causing less impairment of immunological defenses against bacteria and viruses.— James D. Hardy, The World of Surgery, 1986 Cyclosporin, an antirejection drug that helps make organ transplants feasible, comes from a Norwegian fungus.— Jon R. Luoma, Audubon, March 1996 Prolonged treatment with glucocorticoids can have undesirable side effects (including diabetes mellitus), while cyclosporine A can cause diarrhea and vomiting (and diminished bank accounts for owners of large dogs).Dog Watch, July 2007

Note: Trademarks for cyclosporine include Neoral, Restasis, and Sandimmune.

More from Merriam-Webster on cyclosporine

Britannica.com: Encyclopedia article about cyclosporine

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