cyclosporine

noun cy·clo·spor·ine \ ˌsī-klə-ˈspȯr-ən , -ˌēn \
variants: or less commonly cyclosporin play \ˌsī-klə-ˈspȯr-ən\

Definition of cyclosporine

:an immunosuppressive drug C62H111N11O12 that is a cyclic polypeptide obtained as a metabolite from a fungus (Beauveria nivea synonym Tolypocladium inflatum) and is used especially to prevent rejection of transplanted organs and in the treatment of rheumatoid arthritis and psoriasis

Recent Examples of cyclosporine from the Web

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Origin and Etymology of cyclosporine

International Scientific Vocabulary cycl- + spor- + 2-ine


Medical Dictionary

cyclosporine

noun cy·clo·spor·ine \ ˌsī-klə-ˈspȯr-ᵊn, -ˌēn \
variants: also cyclosporin \ˌsī-klə-ˈspȯr-ᵊn\ or cyclosporine A or cyclosporin A or chiefly British ciclosporin or ciclosporin A

medical Definition of cyclosporine

:a cyclosporin C62H111N11O12 that is an immunosuppressive cyclic polypeptide obtained as a metabolite from a fungus (Beauveria nivea synonym Tolypocladium inflatum) and is used especially to prevent rejection of transplanted organs and in the treatment of rheumatoid arthritis and psoriasis
  • The indications for treatment with cyclosporine are rapidly expanding. Once used only for the prevention of organ transplant rejection, cyclosporine is now approved for psoriasis and rheumatoid arthritis and is being prescribed for conditions ranging from autoimmune diseases to atopic dermatitis.
  • —Mark LebwohlScientitic American Medicine BulletinFebruary 2000
  • Recently, cyclosporine has come on the market as an especially useful immunosuppressive agent, since it offers essentially equal protection from rejection of the transplant, while causing less impairment of immunological defenses against bacteria and viruses.
  • —James D. HardyThe World of Surgery1986
  • Cyclosporin, an antirejection drug that helps make organ transplants feasible, comes from a Norwegian fungus.
  • —Jon R. LuomaAudubonMarch 1996
  • Prolonged treatment with glucocorticoids can have undesirable side effects (including diabetes mellitus), while cyclosporine A can cause diarrhea and vomiting (and diminished bank accounts for owners of large dogs).
  • Dog WatchJuly 2007
Note: Trademarks for cyclosporine include Neoral, Restasis, and Sandimmune.

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