congenital adrenal hyperplasia

noun

Definition of congenital adrenal hyperplasia

: any of several disorders that are marked by an inadequate synthesis of cortisol and often aldosterone, are typically characterized by excessive production of androgens, virilization of female external genitalia, and hypertension, and include a severe form resulting in dangerously low levels of sodium and high levels of potassium in the blood shortly after birth

Note: Congenital adrenal hyperplasia is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

abbreviation CAH

Examples of congenital adrenal hyperplasia in a Sentence

Recent Examples on the Web One fascinating example comes from the work of neuroscientist Melissa Hines, who studied girls with congenital adrenal hyperplasia, a condition in which intersex traits arise in XX females because of unusually high levels of androgens. Grace Huckins, Scientific American, "Hormone Levels Are Being Used to Discriminate against Female Athletes," 1 Feb. 2021 Cystic fibrosis, hemophilia, thalassemia and congenital adrenal hyperplasia, which leads to an overproduction of male hormones, are some of the diseases which can now be predicted by NIPT, according to Lo. Julie Zaugg, CNN, "Blood smuggling in China: Why pregnant women are breaking the law to find out their babies' sex," 13 Oct. 2019 This can also happen with other health conditions like Cushing’s syndrome or congenital adrenal hyperplasia, so doctors will try to rule out other health conditions before assuming excess androgen points to PCOS. Mary Claire Lagroue, SELF, "Why Is PCOS Still So Hard for Doctors to Understand?," 12 Sep. 2019

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'congenital adrenal hyperplasia.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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First Known Use of congenital adrenal hyperplasia

1949, in the meaning defined above

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The first known use of congenital adrenal hyperplasia was in 1949

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Cite this Entry

“Congenital adrenal hyperplasia.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/congenital%20adrenal%20hyperplasia. Accessed 16 May. 2021.

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More Definitions for congenital adrenal hyperplasia

congenital adrenal hyperplasia

noun

Medical Definition of congenital adrenal hyperplasia

: any of several hereditary disorders that are marked by inadequate synthesis of cortisol and often aldosterone, are typically characterized by excessive production of androgens, virilization of female external genitalia, and hypertension, and include a severe form resulting in potentially fatal hyponatremia and hyperkalemia shortly after birth

Note: Congenital adrenal hyperplasia is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

Girls with congenital adrenal hyperplasia may emerge from the womb looking like boys, with an enlarged clitoris and even a scrotal sac, although they have fully formed ovaries and uterus.— Natalie Angier, The New York Times, 3 May 1994 abbreviation CAH

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