ataxia-telangiectasia

noun
atax·​ia-tel·​an·​gi·​ec·​ta·​sia | \ -ˌte-ˌlan-jē-ˌek-ˈtā-zh(ē-)ə How to pronounce ataxia-telangiectasia (audio) , -tē-, -tə-\

Definition of ataxia-telangiectasia

: an inherited systemic disorder marked especially by progressive pathological changes in the nervous system resulting in loss of motor coordination and by increased susceptibility to cancer especially of lymphoid tissue

First Known Use of ataxia-telangiectasia

1957, in the meaning defined above

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Dictionary Entries near ataxia-telangiectasia

atavist

atavus

ataxia

ataxia-telangiectasia

ataxite

ataxonomic

Atayal

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The first known use of ataxia-telangiectasia was in 1957

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ataxia-telangiectasia

noun

Medical Definition of ataxia-telangiectasia

: an inherited, systemic disorder that is marked especially by progressive pathological changes in the nervous system resulting in loss of motor coordination, telangiectasias especially on the eyes, ears, and cheeks, and immunodeficiency leading to increased susceptibility to cancer especially of lymphoid tissue Many children with ataxia-telangiectasia die from respiratory failure or cancer by their teens or early 20s.— Bill Minutaglio, The Dallas Morning News, 22 Dec. 1994 Defects in such a multifunctional protein might explain many of the clinical manifestations seen in patients with ataxia–telangiectasia.— Michael Kastan, The New England Journal of Medicine, 7 Sept. 1995

Note: Ataxia-telangiectasia is inherited as a recessive autosomal trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

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