apoptosis

noun

ap·o·pto·sis | \ ˌa-pəp-ˈtō-səs

, -pə-ˈtō-\

plural apoptoses\ ˌa-pəp-ˈtō-ˌsēz

, -pə-ˈtō- \

Definition of apoptosis

: a genetically directed process of cell self-destruction that is marked by the fragmentation of nuclear DNA, is activated either by the presence of a stimulus or removal of a suppressing agent or stimulus, is a normal physiological process eliminating DNA-damaged, superfluous, or unwanted cells, and when halted (as by gene mutation) may result in uncontrolled cell growth and tumor formation

— called also cell suicide, programmed cell death

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If the damage is sufficiently critical, the cell will respond by committing an orderly sort of suicide called apoptosis, which keeps it from causing any further problems. — John Timmer, Ars Technica, "Drugs that kill off old cells may limit a body’s aging," 10 July 2018 Along with colleagues, the pair focused on a core challenge: how to coax myofibroblasts to self-destruct, a cellular process called apoptosis. — Jennifer Couzin-frankel, Science | AAAS, "Pushing cells to self-destruct combats deadly fibrosis," 13 Dec. 2017 These proteins can both induce or prevent apoptosis, and the team suspected that the balance between these proteins was disrupted in the overactive myofibroblasts. — Jennifer Couzin-frankel, Science | AAAS, "Pushing cells to self-destruct combats deadly fibrosis," 13 Dec. 2017 These impostors could then be used to dupe overactive immune cells into believing that apoptosis rather than necrosis was taking place. — The Economist, "Molecular biologyFaking cellular suicide could help control inflammation," 14 Sep. 2017 Unlike necrosis, the leftovers of apoptosis are mostly tolerated by the immune system. — The Economist, "Molecular biologyFaking cellular suicide could help control inflammation," 14 Sep. 2017

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'apoptosis.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

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apoplectiform septicemia

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23 Apr 2019

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The first known use of apoptosis was in 1972

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apoptosis

noun

ap·o·pto·sis | \ ˌa-pəp-ˈtō-səs, -pə-ˈtō-\

plural apoptoses\ -ˌsēz

Medical Definition of apoptosis

: a genetically determined process of cell self-destruction that is marked by the fragmentation of nuclear DNA, is activated either by the presence of a stimulus or by the removal of a stimulus or suppressing agent, is a normal physiological process eliminating DNA-damaged, superfluous, or unwanted cells (as immune cells targeted against the self in the development of self-tolerance or larval cells in amphibians undergoing metamorphosis), and when halted (as by gene mutation) may result in uncontrolled cell growth and tumor formation

— called also cell suicide, programmed cell death