an·​ti·​psy·​chot·​ic ˌan-tē-sī-ˈkä-tik How to pronounce antipsychotic (audio)
: any of the powerful tranquilizers (such as the phenothiazines and butyrophenones) used especially to treat psychosis and believed to act by blocking dopamine nervous receptors

called also neuroleptic

antipsychotic adjective

Examples of antipsychotic in a Sentence

Recent Examples on the Web For people taking medication to treat such conditions, staying hydrated is key as certain antidepressants and antipsychotics can interfere with the body’s ability to regulate temperature. Noor Adatia, Dallas News, 7 Aug. 2023 Multiple chemicals are prescribed, often more than one similar antipsychotic simultaneously, in an attempt to quell the psyche. New York Times, 17 May 2022 So the medical workers came armed with Thorazine, a powerful antipsychotic that resolves a frightening drug experience much as a ballistic missile resolves a ground skirmish. WIRED, 29 June 2023 Like other psychotropic medications, antipsychotics work by tinkering with neurotransmitters. Avery Hurt, Discover Magazine, 22 Mar. 2023 Rexulti was originally approved as an atypical antipsychotic that could be used as an add-on to antidepressants to treat major depressive disorders and schizophrenia. Mira Miller, Verywell Health, 16 May 2023 Additionally, people on certain medications, including some antidepressants and antipsychotics, can have trouble regulating temperature. Mary Kekatos, ABC News, 15 May 2023 These include anti-anxiety medications, antidepressants, antipsychotics and stimulants. Avery Hurt, Discover Magazine, 22 Mar. 2023 Doctors can provide some therapies to ease symptoms, Dr. Appleby said, which may include antidepressants or antipsychotics for behavioral instabilities, or occupational, speech and language, or other therapies.8 Researchers are also looking for more ways to recognize and prevent FTD. Julia Landwehr, Health, 17 Feb. 2023 See More

These examples are programmatically compiled from various online sources to illustrate current usage of the word 'antipsychotic.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

Word History

First Known Use

1958, in the meaning defined above

Time Traveler
The first known use of antipsychotic was in 1958

Dictionary Entries Near antipsychotic

Cite this Entry

“Antipsychotic.” Dictionary, Merriam-Webster, Accessed 28 Sep. 2023.

Medical Definition


1 of 2 adjective
an·​ti·​psy·​chot·​ic ˌant-i-sī-ˈkät-ik, ˌan-ˌtī- How to pronounce antipsychotic (audio)
: of, being, or involving the use of an antipsychotic
antipsychotic drugs


2 of 2 noun
: any of the powerful tranquilizers (as the phenothiazines or butyrophenones) used especially to treat psychosis and believed to act by blocking dopamine nervous receptors

called also neuroleptic

Last Updated: - Updated example sentences
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