an·​ti·​psy·​chot·​ic | \ ˌan-tē-sī-ˈkä-tik How to pronounce antipsychotic (audio) , ˌan-tī- \

Definition of antipsychotic

: any of the powerful tranquilizers (such as the phenothiazines and butyrophenones) used especially to treat psychosis and believed to act by blocking dopamine nervous receptors

called also neuroleptic

Other Words from antipsychotic

antipsychotic adjective

Examples of antipsychotic in a Sentence

Recent Examples on the Web Thorazine was followed by Haldol, a more potent antipsychotic whose side effects were no kinder. New York Times, 17 May 2022 What else could explain why a highly effective antipsychotic is saddled with such cumbersome regulations, while providers routinely prescribe many other medications with similar agranulocytosis risks that have no REMS requirements? Brian Barnett, STAT, 9 May 2022 The first line of treatment might involve using an atypical antipsychotic to stop mania. Jessica Migala,, 28 June 2021 In 2004, Robbie punched an uncle at a family cabin, and was escorted to the hospital by sheriff’s deputies, who later tackled him to the ground so that a nurse could inject him with an antipsychotic. Abe Streep, The New Yorker, 21 May 2021 Doctors then forcibly administered an intramuscular injection of Geodon, a powerful antipsychotic. David Kortava, Harper's Magazine, 16 Mar. 2021 That first day at the nursing home, staff gave Ms. Hill Haldol, a powerful antipsychotic, her medical records show. New York Times, 13 Mar. 2021 Paulson was prescribed Haldol, an antipsychotic for emergency situations and Zoloft for depression. Hillary Gavan, Star Tribune, 8 Aug. 2020 Behavioral interventions may also help people maintain their weight while on these drugs, according to a 2015 study of 200 people with severe mental illness who had been taking an antipsychotic for at least one month and were overweight or obese. Andrea Alfano, Scientific American, 1 July 2015 See More

These example sentences are selected automatically from various online news sources to reflect current usage of the word 'antipsychotic.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. Send us feedback.

First Known Use of antipsychotic

1958, in the meaning defined above

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The first known use of antipsychotic was in 1958

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Last Updated

23 May 2022

Cite this Entry

“Antipsychotic.” Dictionary, Merriam-Webster, Accessed 25 May. 2022.

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More Definitions for antipsychotic


an·​ti·​psy·​chot·​ic | \ ˌant-i-sī-ˈkät-ik, ˌan-ˌtī- How to pronounce antipsychotic (audio) \

Medical Definition of antipsychotic

 (Entry 1 of 2)

: of, being, or involving the use of an antipsychotic antipsychotic drugs



Medical Definition of antipsychotic (Entry 2 of 2)

: any of the powerful tranquilizers (as the phenothiazines or butyrophenones) used especially to treat psychosis and believed to act by blocking dopamine nervous receptors

called also neuroleptic


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