antagonize

verb

an·​tag·​o·​nize an-ˈta-gə-ˌnīz How to pronounce antagonize (audio)
antagonized; antagonizing
Synonyms of antagonize

transitive verb

1
: to incur or provoke the hostility of
His criticism antagonized his friends.
2
: to act in opposition to : counteract
The drug is antagonized by methylxanthines, such as caffeine and theophylline …Scientific American Medicine

Examples of antagonize in a Sentence

He didn't mean to antagonize you. Her comments antagonized many people.
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Investor Michael Burry—of Big Short fame—considered antagonizing the richest man on the planet over the IPO of his latest company. Eleanor Pringle, Fortune, 17 June 2026 Lots of contestants antagonize Alex for fun, but few dare to relentlessly prod both Alex and Greg in the span of the same show. Matthew Jackson, Vulture, 12 June 2026 The 38-year-old was known as one of the NHL’s best power forwards throughout parts of his career, often antagonizing opposing teams and even fan bases, primarily during his time in Boston. Julian McKenzie, New York Times, 8 June 2026 Haverill is introduced in season 1 as a domineering borough commander who antagonizes Det. Britt Hayes, Entertainment Weekly, 5 June 2026 See All Example Sentences for antagonize

Word History

Etymology

Greek antagōnizesthai, from anti- + agōnizesthai to struggle, from agōn contest — more at agony

First Known Use

circa 1742, in the meaning defined at sense 2

Time Traveler
The first known use of antagonize was circa 1742

Browse Nearby Words

Cite this Entry

“Antagonize.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/antagonize. Accessed 20 Jun. 2026.

Kids Definition

antagonize

verb
an·​tag·​o·​nize an-ˈtag-ə-ˌnīz How to pronounce antagonize (audio)
antagonized; antagonizing
: to stir up dislike or anger in

Medical Definition

antagonize

transitive verb
an·​tag·​o·​nize
variants also British antagonise
antagonized also British antagonised; antagonizing also British antagonising
: to act in antagonism to : counteract
these effects are antagonized by atropineErnest Bueding & Harry Most

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