Definition of acetylcholinesterase
: an enzyme that occurs especially in some nerve endings and in the blood and promotes the hydrolysis of acetylcholine
First Known Use of acetylcholinesterase
Medical Definition of acetylcholinesterase
: an enzyme that occurs chiefly in cholinergic nerve endings and promotes the hydrolysis of acetylcholine : cholinesterase 1 <The therapeutic rationale is that inhibition of acetylcholinesterase enhances sympathetic ganglionic neurotransmission and that the effect is maximal when the patient is upright, since sympathetic-nerve traffic is greatest in this position.—Roy Freeman, The New England Journal of Medicine, 7 Feb. 2008> <Tacrine is a potent, centrally active, reversible acetylcholinesterase inhibitor that prevents the degradation of endogenously released acetylcholine.—Margaret J. Knapp et al., The Journal of the American Medical Association, 6 Apr. 1994> ◆Acetylcholinesterase is also found in red blood cells where its function there is unknown.
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