1
: not opposed
an unopposed invasion
: having no opponent
a politician who is running for election unopposed
2
medical : being or relating to estrogen replacement therapy in which a progestin (such as medroxyprogesterone acetate) is not coadministered to reduce the potential risks (such as endometrial cancer) associated with estrogen used alone
A woman who has had her uterus removed can take the estrogen "unopposed"—that is, without the addition of progestin.Consumer Reports

Examples of unopposed in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Both candidates ran unopposed in their respective primary elections. Saige Miller, NPR, 22 July 2026 JoAnna Mendoza, a Marine Corps veteran, ran unopposed in the Democratic primary for that seat. Phillip M. Bailey, USA Today, 22 July 2026 Andy Burnham, newly appointed as the leader of the Labour Party in the United Kingdom, will be waltzing into 10 Downing Street on Monday after an unopposed campaign to replace Prime Minister Keir Starmer. Timothy Nerozzi, The Washington Examiner, 19 July 2026 Spurs nearly went down twice in the last two seasons, despite winning the Europa, Palace won the Conference league despite finishing 15th, and Villa won the Europa nearly unopposed, other than their semi against Forest, who finished 16th. Nnamdi Onyeagwara, New York Times, 13 July 2026 See All Example Sentences for unopposed

Word History

First Known Use

1625, in the meaning defined at sense 1

Time Traveler
The first known use of unopposed was in 1625

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Cite this Entry

“Unopposed.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/unopposed. Accessed 27 Jul. 2026.

Medical Definition

unopposed

adjective
: being or relating to estrogen replacement therapy in which a progestin (as medroxyprogesterone acetate) is not coadministered to reduce the potential risks (as endometrial cancer) associated with estrogen used alone
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