smallpox
noun
small·pox
ˈsmȯl-ˌpäks 
: an acute contagious febrile disease of humans that is caused by a poxvirus (species Variola virus of the genus Orthopoxvirus), is characterized by a skin eruption with pustules, sloughing, and scar formation, and is believed to have been eradicated globally by widespread vaccination
called also variola
Examples of smallpox in a Sentence
Recent Examples on the Web
Shortly after Las Casas’s conversion, a smallpox epidemic swept through Hispaniola, killing, within a few months, nearly a quarter of the island’s population.
—
Greg Grandin
september 23, Literary Hub, 23 Sep. 2025
Throughout their history, the Diné—like many other tribes—have endured devastating epidemics, including smallpox, mumps and pneumonia in the 17th and 18th centuries, which decimated their population.
—Suzette Brewer, Scientific American, 23 Sep. 2025
To prevent outbreaks of this debilitating, disfiguring and deadly disease, state and local governments implemented smallpox inoculation and vaccination campaigns into the early 1900s.
—Stacie Kershner, The Conversation, 22 Sep. 2025
Iron production had ups and downs Historical documents from the Mediterranean and modern-day France suggest that the waves of bubonic plague and smallpox might have contributed to the decline in iron production during the 4th and 5th centuries.
—Maria Mocerino, Interesting Engineering, 14 Sep. 2025
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Greg Grandin
september 23, Literary Hub, 23 Sep. 2025
Throughout their history, the Diné—like many other tribes—have endured devastating epidemics, including smallpox, mumps and pneumonia in the 17th and 18th centuries, which decimated their population.
—Suzette Brewer, Scientific American, 23 Sep. 2025
To prevent outbreaks of this debilitating, disfiguring and deadly disease, state and local governments implemented smallpox inoculation and vaccination campaigns into the early 1900s.
—Stacie Kershner, The Conversation, 22 Sep. 2025
Iron production had ups and downs Historical documents from the Mediterranean and modern-day France suggest that the waves of bubonic plague and smallpox might have contributed to the decline in iron production during the 4th and 5th centuries.
—Maria Mocerino, Interesting Engineering, 14 Sep. 2025
See All Example Sentences for smallpox
Cite this Entry
“Smallpox.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/smallpox. Accessed 1 Oct. 2025.
Copy CitationKids Definition
smallpox
noun
small·pox
ˈsmȯl-ˌpäks
: a sometimes deadly disease that is caused by a virus, is characterized by fever and a skin rash, and is believed to have been wiped out worldwide as a result of vaccination
Medical Definition
smallpox
noun
small·pox
ˈsmȯl-ˌpäks
: an acute contagious febrile disease of humans that is caused by a poxvirus of the genus Orthopoxvirus (species Variola virus), is characterized by skin eruption with pustules, sloughing, and scar formation, and is believed to have been eradicated globally by widespread vaccination
called also variola
see variola major, variola minorLove words? Need even more definitions?
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