irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the state of being irritated

b

: something that irritates

c

: the act of irritating

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part

Synonyms of irritation

• frustration
• exasperation
• annoyance
• displeasure
• grief

Examples of irritation in a Sentence

Dad's general irritation at the incessant complaining coming from the back seat of the car.

Recent Examples on the Web

The Jamaican musical style grew from an encounter between African and European traditions, and its banjos, guitars, hand percussion, and rumba boxes accompanied dancing, drinking, storytelling, and songs about life’s daily irritations. — Emma Madden, Pitchfork, 4 Nov. 2026

The Overnight Hand & Foot Hydration Mask is an intensive overnight treatment combining shea butter, glycerin, panthenol and squalane to deeply hydrate, soften and condition dry skin while helping soothe irritation. — ABC News, 2 Nov. 2026

Solve one recurring irritation before launching a complete overhaul. — Tarot.com, Sun Sentinel, 2 Nov. 2026

Give yourself a little space before irritation starts doing the talking. — Tarot.com, Chicago Tribune, 1 Nov. 2026

Word History

First Known Use

15th century, in the meaning defined at sense 1c

Rhymes for irritation

• abdication
• aberration
• abjuration
• abnegation
• abrogation
• acceptation
• acclamation
• acclimation
• accusation
• activation
• actuation
• acylation

Kids Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

: the act of irritating : the state of being irritated

2

: irritant entry 2

Medical Definition

irritation

noun

ir·​ri·​ta·​tion ˌir-ə-ˈtā-shən 

1

a

: the act of irritating

b

: something that irritates

c

: the state of being irritated

2

: a condition of irritability, soreness, roughness, or inflammation of a bodily part