: one haploid set of chromosomes with the genes they contain
broadly : the genetic material of an organism compare proteome

Examples of genome in a Sentence

Recent Examples on the Web
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Using a detailed reference genome for the tree, the scientists re-sequenced 112 plants from 26 populations spread across its Chinese habitats. New Atlas, 24 July 2026 Overall, the length of the base pairing between the guide RNAs and the genome is on the order of 18 bases long. ArsTechnica, 24 July 2026 Now, researchers are turning to genome science for new strategies for chestnut restoration. Steve Strauss, The Conversation, 22 July 2026 The findings advocate for more comprehensive whole-genome sequencing to fully understand a child's genetic health. William A. Haseltine, Forbes.com, 21 July 2026 See All Example Sentences for genome

Word History

Etymology

German Genom, from Gen gene + -om (as in Chromosom chromosome)

First Known Use

1926, in the meaning defined above

Time Traveler
The first known use of genome was in 1926

Browse Nearby Words

Cite this Entry

“Genome.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/genome. Accessed 28 Jul. 2026.

Medical Definition

: one haploid set of chromosomes with the genes they contain
broadly : the genetic material of an organism
The idea behind sequencing an organism's genome—decoding, letter by letter, the message contained in every last one of its genes—is that it would tell us a lot about how the organism works. Lori Oliwenstein, Discover

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