The President's speech addressed a number of important issues.
campaign issues like education and defense
The issue is poverty, not race: to talk about race is simply to confuse the issue.
The case involves some complicated legal issues.
He should stop dodging the issue and make a decision now.
There's an interesting article on page 12 of this issue.
the most recent issue of the magazine
Origin of ISSUE
Middle English, exit, proceeds, from Anglo-French, from issir to come out, go out, from Latin exire to go out, from ex- + ire to go; akin to Gothic iddja he went, Greek ienai to go, Sanskrit eti he goes
a: a discharge (as of blood) from the body that is caused by disease or other physical disorder or that is produced artificially <a woman having an issue of blood twelve years, which had spent all her living upon physicians—Luke 8:43 (Authorized Version)>b: an incision made to produce such a discharge